Copper- or iron-catalyzed stereoselective methylation of enamides using dicumyl peroxide as the methyl source

被引：3

作者：

Zhang, Fukuan ^{[1
]}

Liu, Haidong ^{[1
]}

Jia, Xin-Jian ^{[1
]}

Li, Lin ^{[1
]}

Liang, Yi ^{[1
]}

Luo, Xuzhong ^{[1
]}

Luo, Haiqing ^{[1
]}

机构：

[1] Gannan Normal Univ, Dept Chem & Chem Engn, Ganzhou 341000, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2023年 / 47卷 / 36期

基金：

中国国家自然科学基金;

关键词：

C-H METHYLATION; METAL-FREE; C(SP(2))-H ARYLSULFONYLATION; TOLUENE DERIVATIVES; BOND; OXIDATION; ACYLATION; ALDEHYDES; ESTERS; FUNCTIONALIZATIONS;

D O I：

10.1039/d3nj02949b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and versatile copper- or iron-catalyzed direct & beta;-C(sp2)-H methylation of enamides by using dicumyl peroxide (DCP) as the methylating reagent has been developed. This methodology provides convenient access to a wide range of & beta;-C(sp2)-methylated enamides with exclusive E-selective control in moderate to good yields. Mechanistic studies reveal that a methyl radical was involved in this transformation. Notably, this method features cheap copper or iron salts as the catalyst, a simple procedure, commercially available methylation reagents, a broad substrate scope, and excellent functional group tolerance. An efficient and versatile copper- or iron-catalyzed direct stereoselective & beta;-C(sp2)-H methylation of enamides by using dicumyl peroxide (DCP) as the methylating reagent has been developed.

引用

页码：17060 / 17065

页数：6

共 35 条

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