Progression of pancreatic neuroendocrine tumors (PanNETs) to metastatic disease is associated with MCT4 expression and metabolic heterogeneity

被引:0
|
作者
Sadowski, M. [1 ]
Brautigam, K. [1 ]
Straub, J. [1 ]
Andreasi, V [2 ]
Kirchner, P. [1 ]
Maire, R. [1 ]
Dettmer, M. [1 ]
Schrader, J. [3 ]
Partelli, S. [2 ]
Falconi, M. [2 ]
Marinoni, I [1 ]
Perren, A. [1 ]
机构
[1] Univ Bern, Bern, Switzerland
[2] Univ Vita Salute San Raffaele, Milan, Italy
[3] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany
关键词
mct4; metabolic subtypes; aggressive pannet; patient-derived tumoroid;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
F19
引用
收藏
页码:149 / 149
页数:1
相关论文
共 50 条
  • [1] Decoding and targeting of metabolic heterogeneity in pancreatic neuroendocrine tumors (PanNETs): MCT1 and MCT4 in the crosshair for precision therapy
    Brautigam, K.
    Straub, J.
    Bihi, A.
    Andreasi, V
    Kirchner, P.
    Dettmer, M.
    Schrader, J.
    Partelli, S.
    Falconi, M.
    Marinoni, I
    Sadowski, M.
    Perren, A.
    JOURNAL OF NEUROENDOCRINOLOGY, 2024, 36 : 48 - 48
  • [2] Change of Lactate Transporter (MCT4) Expression in Pancreatic Microadenomas and Stages of Pancreatic Neuroendocrine Tumors
    Straub, J.
    Brautigam, K.
    Di Domenico, A.
    Galvan, J. A.
    Maire, R.
    Skowronska, M.
    Dettmer, M. S.
    Marinoni, I
    Perren, A.
    NEUROENDOCRINOLOGY, 2020, 110 : 19 - 19
  • [3] Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis
    Sheng, Gaohong
    Gao, Yuan
    Wu, Hua
    Liu, Yang
    Yang, Yong
    JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, 2023, 18 (01)
  • [4] Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis
    Gaohong Sheng
    Yuan Gao
    Hua Wu
    Yang Liu
    Yong Yang
    Journal of Orthopaedic Surgery and Research, 18
  • [5] Role of Tumor-Associated Macrophages in the Clinical Course of Pancreatic Neuroendocrine Tumors (PanNETs)
    Cai, Lei
    Michelakos, Theodoros
    Deshpande, Vikram
    Arora, Kshitij S.
    Yamada, Teppei
    Ting, David T.
    Taylor, Marty S.
    Fernandez-del Castillo, Carlos
    Warshaw, Andrew L.
    Lillemoe, Keith D.
    Ferrone, Soldano
    Ferrone, Cristina R.
    CLINICAL CANCER RESEARCH, 2019, 25 (08) : 2644 - 2655
  • [6] A SYSTEMATIC EVALUATION OF CELL LINEAGE AMONG NONFUNCTIONAL PANCREATIC NEUROENDOCRINE TUMORS (PANNETS) AND THEIR RELATIONSHIP TO GENOMIC ALTERATIONS ASSOCIATED WITH METASTATIC DISEASE AND POOR PATIENT SURVIVAL
    Aijazi, Muaz
    Singhi, Aatur
    Nalesnik, Michael A.
    O'Sullivan, Roderick
    Roy, Somak
    Lee, Kenneth
    Bahary, Nathan
    Brand, Randall
    Chennat, Jennifer
    Kenneth, Fasanella
    McGrath, Kevin
    Nikiforova, Marina N.
    Slivka, Adam
    Hogg, Melissa E.
    Zeh, Herbert J.
    Zureikat, Amer H.
    GASTROENTEROLOGY, 2020, 158 (06) : S69 - S69
  • [7] The Pathologic Characteristics at The Primary Resected Tumor For Pancreatic Neuroendocrine Tumors (PanNETs) That Proved to Have Metastatic Behavior
    Bozkurt, Emre
    Esmer, Rohat
    Saka, Burcu
    Eren, Ozgur
    Bagci, Pelin
    Balci, Serdar
    Armutlu, Ayse
    Sokmensuer, Cenk
    Xue, Yue
    Pehlivanoglu, Burcin
    Reid, Michelle
    Maithel, Shishir
    Kooby, David
    Sarmiento, Juan
    Taskin, Orhun
    Kapran, Yersu
    Gurses, Bengi
    Tellioglu, Gurkan
    Bilge, Orhan
    Basturk, Olca
    Adsay, N. Volkan
    LABORATORY INVESTIGATION, 2023, 103 (03) : S1493 - S1494
  • [8] Factors associated with grade progression in pancreatic neuroendocrine tumors
    Wang, Stephanie J.
    Kidder, Wesley
    Joseph, Nancy M.
    Le, Bryan Khuong
    Lindsay, Sheila
    Moon, Farhana
    Nakakura, Eric K.
    Zhang, Li
    Bergsland, Emily K.
    ENDOCRINE-RELATED CANCER, 2025, 32 (03)
  • [9] Diffuse expression of p16 in pancreatic neuroendocrine tumors (PanNETs) and the association of morphology variants
    Yablonski, John
    Shi, Chanjuan
    Chen, Wei
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2025,
  • [10] Loss of PTEN and Expression of GLUT1 Predict the Metastatic Progression of Pancreatic Neuroendocrine Tumors
    Neyaz, Azfar
    Westendorp, Jasmijn
    Wald, Abigail
    Nikiforova, Marina
    Hong, Seung-Mo
    Heaphy, Christopher
    Brosens, Lodewijk
    Singhi, Aatur
    LABORATORY INVESTIGATION, 2022, 102 (SUPPL 1) : 1225 - 1225