The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential

被引：10
作者：
Yang, Fengguang [1 ,2 ,3 ]
Ma, Jinglin [1 ,2 ,3 ,4 ]
Zhu, Daxue [1 ,2 ,3 ]
Wang, Zhaoheng [1 ,2 ,3 ]
Li, Yanhu [1 ,2 ,3 ]
He, Xuegang [1 ,2 ,3 ]
Zhang, Guangzhi [1 ,2 ,3 ]
Kang, Xuewen [1 ,2 ,3 ]
机构：
[1] Lanzhou Univ, Hosp 2, Dept Orthoped, Lanzhou 730030, Peoples R China
[2] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730030, Peoples R China
[3] Lanzhou Univ, Hosp 2, Orthopaed Key Lab Gansu Prov, Lanzhou 730030, Peoples R China
[4] Lanzhou Univ Technol, Sch Petrochem Engn, Lanzhou 730050, Peoples R China
来源：
BIOMOLECULES | 2023年 / 13卷 / 07期
基金：
中国国家自然科学基金;
关键词：
tumor; Alzheimer's disease; leukemia; endometriosis; myocardial infarction; CALCIUM-BINDING PROTEIN; ACUTE LYMPHOBLASTIC-LEUKEMIA; PROMOTES CELL-PROLIFERATION; INCREASED EXPRESSION; BETA-CATENIN; IMMUNOHISTOCHEMICAL ANALYSIS; DIFFERENTIAL EXPRESSION; MYOCARDIAL-INFARCTION; CYCLE PROGRESSION; OXIDATIVE STRESS;
D O I：
10.3390/biom13071139
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
S100A6, also known as calcyclin, is a low-molecular-weight Ca2+-binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as melanoma. S100A6 has many molecular functions related to cell proliferation, the cell cycle, cell differentiation, and the cytoskeleton. It is not only involved in tumor invasion, proliferation, and migration, but also the pathogenesis of other non-neoplastic diseases. In this review, we focus on the molecular mechanisms and potential therapeutic targets of S100A6 in tumors, nervous system diseases, leukemia, endometriosis, cardiovascular disease, osteoarthritis, and other related diseases.
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页数：22
相关论文
共 152 条
  • [21] The effect of S100A6 on nuclear translocation of CacyBP/SIP in colon cancer cells
    Feng, Shanshan
    Zhou, Qiaozhi
    Yang, Bo
    Li, Qianqian
    Liu, Aiqin
    Zhao, Yingying
    Qiu, Changqing
    Ge, Jun
    Zhai, Huihong
    [J]. PLOS ONE, 2018, 13 (03):
  • [22] FERRARI S, 1992, CANCER RES, V52, P11
  • [23] CALCYCLIN - CA-2+-BINDING PROTEIN HOMOLOGOUS TO GLIAL S-100-BETA IS PRESENT IN NEURONS
    FILIPEK, A
    PUZIANOWSKA, M
    CIESLAK, B
    KUZNICKI, J
    [J]. NEUROREPORT, 1993, 4 (04) : 383 - 386
  • [24] S100A6 and Its Brain Ligands in Neurodegenerative Disorders
    Filipek, Anna
    Lesniak, Wieslawa
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (11)
  • [25] Expression of S100A6 protein in a broad spectrum of cutaneous tumors using tissue microarrays
    Fullen, Douglas R.
    Garrisi, Angela J.
    Sanders, Donita
    Thomas, Dafydd
    [J]. JOURNAL OF CUTANEOUS PATHOLOGY, 2008, 35 : 28 - 34
  • [26] Antibody-Mediated Autoimmune Encephalopathies and Immunotherapies
    Gastaldi, Matteo
    Thouin, Anais
    Vincent, Angela
    [J]. NEUROTHERAPEUTICS, 2016, 13 (01) : 147 - 162
  • [27] Endometriosis
    Giudice, LC
    Kao, LC
    [J]. LANCET, 2004, 364 (9447) : 1789 - 1799
  • [28] The Apoptotic, Angiogenic and Cell Proliferation Genes CD63, S100A6 e GNB2L1 are Altered in Patients with Endometriosis
    Gomes, Valeria Aguiar
    Bonocher, Camila de Moraes
    Rosa-e-Silva, Julio Cesar
    Paro de Paz, Claudia Cristina
    Ferriani, Rui Alberto
    Meola, Juliana
    [J]. REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA, 2018, 40 (10): : 606 - 613
  • [29] S100A6 is a critical regulator of hematopoietic stem cells
    Grahn, Tan Hooi Min
    Niroula, Abhishek
    Vegvari, Akos
    Oburoglu, Leal
    Pertesi, Maroulio
    Warsi, Sarah
    Safi, Fatemeh
    Miharada, Natsumi
    Garcia, Sandra C.
    Siva, Kavitha
    Liu, Yang
    Rorby, Emma
    Nilsson, Bjorn
    Zubarev, Roman A.
    Karlsson, Stefan
    [J]. LEUKEMIA, 2020, 34 (12) : 3323 - 3337
  • [30] Distinct functional brain regional integration of Casp3, Ascl1 and S100a6 gene expression in spatial memory
    Gruden, Marina A.
    Storozheva, Zinaida I.
    Sewell, Robert D. E.
    Kolobov, Vitaly V.
    Sherstnev, Vladimir V.
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2013, 252 : 230 - 238
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