The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential

被引：10
作者：
Yang, Fengguang [1 ,2 ,3 ]
Ma, Jinglin [1 ,2 ,3 ,4 ]
Zhu, Daxue [1 ,2 ,3 ]
Wang, Zhaoheng [1 ,2 ,3 ]
Li, Yanhu [1 ,2 ,3 ]
He, Xuegang [1 ,2 ,3 ]
Zhang, Guangzhi [1 ,2 ,3 ]
Kang, Xuewen [1 ,2 ,3 ]
机构：
[1] Lanzhou Univ, Hosp 2, Dept Orthoped, Lanzhou 730030, Peoples R China
[2] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730030, Peoples R China
[3] Lanzhou Univ, Hosp 2, Orthopaed Key Lab Gansu Prov, Lanzhou 730030, Peoples R China
[4] Lanzhou Univ Technol, Sch Petrochem Engn, Lanzhou 730050, Peoples R China
来源：
BIOMOLECULES | 2023年 / 13卷 / 07期
基金：
中国国家自然科学基金;
关键词：
tumor; Alzheimer's disease; leukemia; endometriosis; myocardial infarction; CALCIUM-BINDING PROTEIN; ACUTE LYMPHOBLASTIC-LEUKEMIA; PROMOTES CELL-PROLIFERATION; INCREASED EXPRESSION; BETA-CATENIN; IMMUNOHISTOCHEMICAL ANALYSIS; DIFFERENTIAL EXPRESSION; MYOCARDIAL-INFARCTION; CYCLE PROGRESSION; OXIDATIVE STRESS;
D O I：
10.3390/biom13071139
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
S100A6, also known as calcyclin, is a low-molecular-weight Ca2+-binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as melanoma. S100A6 has many molecular functions related to cell proliferation, the cell cycle, cell differentiation, and the cytoskeleton. It is not only involved in tumor invasion, proliferation, and migration, but also the pathogenesis of other non-neoplastic diseases. In this review, we focus on the molecular mechanisms and potential therapeutic targets of S100A6 in tumors, nervous system diseases, leukemia, endometriosis, cardiovascular disease, osteoarthritis, and other related diseases.
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页数：22
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