Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer

被引：19

作者：

Wang, Yuexin ^{[1
]}

Zhang, Zhiyuan ^{[1
]}

Yang, Qiuli ^{[1
]}

Cao, Yejin ^{[1
]}

Dong, Yingjie ^{[1
]}

Bi, Yujing ^{[2
]}

Liu, Guangwei ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Life Sci, Key Lab Cell Proliferat & Regulat Biol, Minist Educ, Beijing 100875, Peoples R China

[2] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 01期

关键词：

Piezo1; mechanosensitive ion channel; immunity; inflammation; cancer; cancer immunotherapy; virus infection; lung; MECHANISM; ARCHITECTURE; ACTIVATION;

D O I：

10.3390/molecules28010213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Piezo1 was originally identified as a mechanically activated, nonselective cation ion channel, with significant permeability to calcium ions, is evolutionally conserved, and is involved in the proliferation and development of various types of cells, in the context of various types of mechanical or innate stimuli. Recently, our study and work by others have reported that Piezo1 from all kinds of immune cells is involved in regulating many diseases, including infectious inflammation and cancer. This review summarizes the recent progress made in understanding the immunoregulatory role and mechanisms of the mechanical receptor Piezo1 in inflammation and cancer and provides new insight into the biological significance of Piezo1 in regulating immunity and tumors.

引用

页数：14

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