Comprehensive Risk Assessment of Infection Induced by SARS-CoV-2

被引:1
作者
Megha, KB. [1 ]
Reshma, S. [1 ]
Amir, S. [1 ]
Krishnan, MJ. Ajai [1 ]
Shimona, A. [2 ,3 ]
Alka, Rao [2 ,3 ]
Mohanan, PV. [1 ]
机构
[1] Govt India, Sree Chitra Tirunal Inst Med Sci & Technol, Toxicol Div, Biomed Technol Wing, Trivandrum 695012, Kerala, India
[2] CSIR Inst Microbial Technol, Sect 39 A, Chandigarh 160036, India
[3] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
关键词
SARS-CoV-2; Post-COVID immunity; COVID-19; recovery; Long COVID; Post-COVID complications; ACUTE RESPIRATORY SYNDROME; HUMAN CORONAVIRUS NL63; HEPARAN-SULFATE; SARS CORONAVIRUS; CATHEPSIN-L; COVID-19; ATTACHMENT; EXPRESSION; RECEPTOR; PROTEIN;
D O I
10.1007/s12035-023-03682-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The pandemic COVID-19 (coronavirus disease 2019) is caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), which devastated the global economy and healthcare system. The infection caused an unforeseen rise in COVID-19 patients and increased the mortality rate globally. This study gives an overall idea about host-pathogen interaction, immune responses to COVID-19, recovery status of infection, targeted organs and complications associated, and comparison of post-infection immunity in convalescent subjects and non-infected individuals. The emergence of the variants and episodes of COVID-19 infections made the situation worsen. The timely introduction of vaccines and precautionary measures helped control the infection's severity. Later, the population that recovered from COVID-19 grew significantly. However, understanding the impact of healthcare issues resulting after infection is paramount for improving an individual's health status. It is now recognised that COVID-19 infection affects multiple organs and exhibits a broad range of clinical manifestations. So, post COVID-19 infection creates a high risk in individuals with already prevailing health complications. The identification of post-COVID-19-related health issues and their appropriate management is of greater importance to improving patient's quality of life. The persistence, sequelae and other medical complications that normally last from weeks to months after the recovery of the initial infection are involved with COVID-19. A multi-disciplinary approach is necessary for the development of preventive measures, techniques for rehabilitation and strategies for clinical management when it comes to long-term care.
引用
收藏
页码:9851 / 9872
页数:22
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