ALDEFLUOR activity, ALDH isoforms, and their clinical significance in cancers

被引：15
作者：
Duan, Jiang-Jie [1 ,2 ,3 ,4 ]
Cai, Jiao [1 ,2 ,3 ,4 ]
Gao, Lei [5 ]
Yu, Shi-Cang [1 ,2 ,3 ,4 ,6 ,7 ]
机构：
[1] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Stem Cell & Regenerat Med, Chongqing, Peoples R China
[2] Minist Sci & Technol, Int Joint Res Ctr Precis Biotherapy, Chongqing, Peoples R China
[3] Southwest Hosp, Inst Pathol, Southwest Canc Ctr, Chongqing, Peoples R China
[4] Minist Educ, Key Lab Canc Immunopathol, Chongqing, Peoples R China
[5] Third Med Univ, Army Med Univ, Xinqiao Hosp, Dept Hematol, Chongqing, Peoples R China
[6] Jin feng Lab, Chongqing, Peoples R China
[7] Third Mil Med Univ, Army Med Univ, Dept Stem Cell & Regenerat Med, Chongqing 400038, Peoples R China
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2023年 / 38卷 / 01期
基金：
中国国家自然科学基金;
关键词：
ALDH; ALDEFLUOR; tumour; stem cell; inhibitor; ALDEHYDE DEHYDROGENASE 1; SQUAMOUS-CELL CARCINOMA; TUMOR-INITIATING CELLS; RNAI-MEDIATED KNOCKDOWN; ACUTE MYELOID-LEUKEMIA; LYMPH-NODE METASTASIS; STEM-LIKE CELLS; CORD BLOOD; REDUCES CHEMOTHERAPY; METABOLIZING ENZYMES;
D O I：
10.1080/14756366.2023.2166035
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
High aldehyde dehydrogenase (ALDH) activity is a metabolic feature of adult stem cells and various cancer stem cells (CSCs). The ALDEFLUOR system is currently the most commonly used method for evaluating ALDH enzyme activity in viable cells. This system is applied extensively in the isolation of normal stem cells and CSCs from heterogeneous cell populations. For many years, ALDH1A1 has been considered the most important subtype among the 19 ALDH family members in determining ALDEFLUOR activity. However, in recent years, studies of many types of normal and tumour tissues have demonstrated that other ALDH subtypes can also significantly influence ALDEFLUOR activity. In this article, we briefly review the relationships between various members of the ALDH family and ALDEFLUOR activity. The clinical significance of these ALDH isoforms in different cancers and possible directions for future studies are also summarised.
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页数：19
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