Algorithms push forward the application of MALDI-TOF mass fingerprinting in rapid precise diagnosis

被引：9

作者：

Zhu, Yingdi ^{[1
,2
]}

Girault, Hubert H. ^{[2
]}

机构：

[1] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Chinese Acad Sci,Canc Hosp, Hangzhou, Peoples R China

[2] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Sch Basic Sci, Lausanne, Switzerland

来源：

VIEW | 2023年 / 4卷 / 02期

关键词：

antimicrobial susceptibility testing; biomarker discovery; MALDI-TOF mass fingerprinting; microbial identification; rapid precise diagnosis; LASER-DESORPTION IONIZATION; BACTERIAL IDENTIFICATION; SPECIES IDENTIFICATION; BIOMARKER DISCOVERY; PROTEIN PROFILES; SPECTROMETRY; TIME; DESORPTION/IONIZATION; NORMALIZATION; PHOTOCATALYSIS;

D O I：

10.1002/VIW.20220042

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Macromolecular mass fingerprinting using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is a quick tool for biochemical analysis. In combination with algorithms for automated data analysis and interpretation, it has wide application potentials in life science, especially for diagnostic purposes. This review aims to illustrate recent advances of this analytical tool, focusing on the improvement of the experimental techniques, the data analysis algorithms, and more importantly the applications in rapid precise diagnosis.

引用

页数：10

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