Antibacterial lanostane triterpenoids from Ganoderma tsugae

被引：2

作者：

Hu, Jiang ^{[1
]}

Li, Guo-Fen ^{[2
]}

Xu, Feng-Ming ^{[3
]}

Li, Qiang ^{[1
]}

Lv, Tao ^{[1
]}

Peng, Tian-Feng ^{[1
]}

Yin, Si ^{[1
]}

Gong, Wei ^{[4
]}

机构：

[1] Qujing Normal Univ, Coll Biol Resources & Food Engn, Qujing 655011, Peoples R China

[2] Maternal & Child Hlth & Family Planning Serv Ctr Z, Zhanyi 655331, Peoples R China

[3] First People Hosp Qujing, Dept Internal Neurol, Qujing 655000, Peoples R China

[4] Shenyang Joint Logist Support Ctr Drug Instrument, Dept Food & Drug Inspect, Shenyang 110026, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2024年 / 26卷 / 05期

关键词：

Ganodermataceae; Ganoderma tsugae; lanostane triterpenoids; antibacterial activity; LUCIDUM POLYSACCHARIDE; FRUITING BODIES; MUSHROOM;

D O I：

10.1080/10286020.2023.2260749

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A phytochemical investigation on the 80% EtOH extract of the fruiting bodies of Ganoderma tsugae resulted into the isolation of two previously undescribed lanostane triterpenoids, 7,11-dioxo-3 beta-acetyloxy-26,27-dihydroxy-lanosta-8,24-diene (1) and 7,20-dioxo-3 beta-acetyloxy-11 beta,15 alpha-dihydroxy-22,23,24,25,26,27-hexanorlanosta-8-ene (2), togeher with one known lanostane triterpenoid ganodermanontriol (3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their antibacterial activities against six pathogenic microorganisms. Compound 3 exhibited some activities against three Gram positive bacteria with MIC values less than 30 mu g/ml.

引用

页码：541 / 547

页数：7

共 17 条

[1] Secondary metabolites from Ganoderma
Baby, Sabulal
Johnson, Anil John
Govindan, Balaji
[J]. PHYTOCHEMISTRY, 2015, 114 : 66 - 101
[2] CNS anti-depressant, anxiolytic and analgesic effects of Ganoderma applanatum (mushroom) along with ligand-receptor binding screening provide new insights: Multi-disciplinary approaches
Hossen, S. M. Moazzem
Islam, Mohammad Jahedul
Hossain, Md Rabiul
Barua, Anik
Uddin, Md Giash
Emon, Nazim Uddin
[J]. BIOCHEMISTRY AND BIOPHYSICS REPORTS, 2021, 27
[3] Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum
Huang, Sheng-Zhuo
Ma, Qing-Yun
Kong, Fan-Dong
Guo, Zhi-Kai
Cai, Cai-Hong
Hu, Li-Li
Zhou, Li-Man
Wang, Qi
Dai, Hao-Fu
Mei, Wen-Li
Zhao, You-Xing
[J]. PHYTOCHEMISTRY, 2017, 143 : 104 - 110
[4] Polyoxygenated ergostane-type sterols from the liquid culture of Ganoderma applanatum
Lee, So Young
Kim, Ju Sun
Lee, Sanghyun
Kang, Sam Sik
[J]. NATURAL PRODUCT RESEARCH, 2011, 25 (14) : 1304 - 1311
[5] Triterpenoids and an alkamide from Ganoderma tsugae
Lin, Kai-Wei
Maitraie, Dravidum
Huang, A-Mei
Wang, Jih-Pyang
Lin, Chun-Nan
[J]. FITOTERAPIA, 2016, 108 : 73 - 80
[6] Xanthine oxidase inhibitory lanostanoids from Ganoderma tsugae
Lin, Kai-Wei
Chen, Yen-Ting
Yang, Shyh-Chyun
Wei, Bai-Luh
Hung, Chi-Feng
Lin, Chun-Nan
[J]. FITOTERAPIA, 2013, 89 : 231 - 238
[7] Protective effect of Ganoderma lucidum polysaccharide against carbon tetrachloride-induced hepatic damage in precision-cut carp liver slices
Liu, Yingjuan
Zhang, Chunyun
Du, Jinliang
Jia, Rui
Cao, Liping
Jeney, Galina
Teraoka, Hiroki
Xu, Pao
Yin, Guojun
[J]. FISH PHYSIOLOGY AND BIOCHEMISTRY, 2017, 43 (05) : 1209 - 1221
[8] Lanostane-type triterpenoids from the fruiting bodies of Ganoderma applanatum
Peng, XingRong
Li, Lei
Dong, JinRun
Lu, ShuangYang
Lu, Jing
Li, XiaoNian
Zhou, Lin
Qiu, MingHua
[J]. PHYTOCHEMISTRY, 2019, 157 : 103 - 110
[9] Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum
Qiu, Junming
Wang, Xiang
Song, Chengguang
[J]. FITOTERAPIA, 2016, 109 : 75 - 79
[10] Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-β1 from prostate cancer cells
Stanley, G
Harvey, K
Slivova, V
Jiang, JH
Sliva, D
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 330 (01) : 46 - 52

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