Antibacterial lanostane triterpenoids from Ganoderma tsugae

被引：3

作者：

Hu, Jiang ^{[1
]}

Li, Guo-Fen ^{[2
]}

Xu, Feng-Ming ^{[3
]}

Li, Qiang ^{[1
]}

Lv, Tao ^{[1
]}

Peng, Tian-Feng ^{[1
]}

Yin, Si ^{[1
]}

Gong, Wei ^{[4
]}

机构：

[1] Qujing Normal Univ, Coll Biol Resources & Food Engn, Qujing 655011, Peoples R China

[2] Maternal & Child Hlth & Family Planning Serv Ctr Z, Zhanyi 655331, Peoples R China

[3] First People Hosp Qujing, Dept Internal Neurol, Qujing 655000, Peoples R China

[4] Shenyang Joint Logist Support Ctr Drug Instrument, Dept Food & Drug Inspect, Shenyang 110026, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2024年 / 26卷 / 05期

关键词：

Ganodermataceae; Ganoderma tsugae; lanostane triterpenoids; antibacterial activity; LUCIDUM POLYSACCHARIDE; FRUITING BODIES; MUSHROOM;

D O I：

10.1080/10286020.2023.2260749

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A phytochemical investigation on the 80% EtOH extract of the fruiting bodies of Ganoderma tsugae resulted into the isolation of two previously undescribed lanostane triterpenoids, 7,11-dioxo-3 beta-acetyloxy-26,27-dihydroxy-lanosta-8,24-diene (1) and 7,20-dioxo-3 beta-acetyloxy-11 beta,15 alpha-dihydroxy-22,23,24,25,26,27-hexanorlanosta-8-ene (2), togeher with one known lanostane triterpenoid ganodermanontriol (3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their antibacterial activities against six pathogenic microorganisms. Compound 3 exhibited some activities against three Gram positive bacteria with MIC values less than 30 mu g/ml.

引用

页码：541 / 547

页数：7

共 17 条

[1] Secondary metabolites from Ganoderma [J].

Baby, Sabulal ;

Johnson, Anil John ;

Govindan, Balaji .

PHYTOCHEMISTRY, 2015, 114 :66-101

[2] CNS anti-depressant, anxiolytic and analgesic effects of Ganoderma applanatum (mushroom) along with ligand-receptor binding screening provide new insights: Multi-disciplinary approaches [J].

Hossen, S. M. Moazzem ;

Islam, Mohammad Jahedul ;

Hossain, Md Rabiul ;

Barua, Anik ;

Uddin, Md Giash ;

Emon, Nazim Uddin .

BIOCHEMISTRY AND BIOPHYSICS REPORTS, 2021, 27

[3] Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum [J].

Huang, Sheng-Zhuo ;

Ma, Qing-Yun ;

Kong, Fan-Dong ;

Guo, Zhi-Kai ;

Cai, Cai-Hong ;

Hu, Li-Li ;

Zhou, Li-Man ;

Wang, Qi ;

Dai, Hao-Fu ;

Mei, Wen-Li ;

Zhao, You-Xing .

PHYTOCHEMISTRY, 2017, 143 :104-110

[4] Polyoxygenated ergostane-type sterols from the liquid culture of Ganoderma applanatum [J].

Lee, So Young ;

Kim, Ju Sun ;

Lee, Sanghyun ;

Kang, Sam Sik .

NATURAL PRODUCT RESEARCH, 2011, 25 (14) :1304-1311

[5] Triterpenoids and an alkamide from Ganoderma tsugae [J].

Lin, Kai-Wei ;

Maitraie, Dravidum ;

Huang, A-Mei ;

Wang, Jih-Pyang ;

Lin, Chun-Nan .

FITOTERAPIA, 2016, 108 :73-80

[6] Xanthine oxidase inhibitory lanostanoids from Ganoderma tsugae [J].

Lin, Kai-Wei ;

Chen, Yen-Ting ;

Yang, Shyh-Chyun ;

Wei, Bai-Luh ;

Hung, Chi-Feng ;

Lin, Chun-Nan .

FITOTERAPIA, 2013, 89 :231-238

[7] Protective effect of Ganoderma lucidum polysaccharide against carbon tetrachloride-induced hepatic damage in precision-cut carp liver slices [J].

Liu, Yingjuan ;

Zhang, Chunyun ;

Du, Jinliang ;

Jia, Rui ;

Cao, Liping ;

Jeney, Galina ;

Teraoka, Hiroki ;

Xu, Pao ;

Yin, Guojun .

FISH PHYSIOLOGY AND BIOCHEMISTRY, 2017, 43 (05) :1209-1221

[8] Lanostane-type triterpenoids from the fruiting bodies of Ganoderma applanatum [J].

Peng, XingRong ;

Li, Lei ;

Dong, JinRun ;

Lu, ShuangYang ;

Lu, Jing ;

Li, XiaoNian ;

Zhou, Lin ;

Qiu, MingHua .

PHYTOCHEMISTRY, 2019, 157 :103-110

[9] Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum [J].

Qiu, Junming ;

Wang, Xiang ;

Song, Chengguang .

FITOTERAPIA, 2016, 109 :75-79

[10] Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-β1 from prostate cancer cells [J].

Stanley, G ;

Harvey, K ;

Slivova, V ;

Jiang, JH ;

Sliva, D .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 330 (01) :46-52

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