An update on the development of novel antifungal agents for eumycetoma

被引：8
作者：
Chandler, David J. [1 ,2 ]
Bonifaz, Alexandro [3 ]
van de Sande, Wendy W. J. [4 ]
机构：
[1] Brighton & Sussex Med Sch, Dept Global Hlth & Infect, Brighton, England
[2] Univ Hosp Sussex NHS Fdn Trust, Brighton Gen Hosp, Dermatol Dept, Brighton, England
[3] Hosp Gen Mexico Dr Eduardo Liceaga, Mexico City, Mexico
[4] Erasmus MC, Univ Med Ctr Rotterdam, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
来源：
FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷
关键词：
eumycetoma; Neglected Tropical Disease (NTD); mycology; skin NTDs; Madurella mycetomatis; IN-VITRO SUSCEPTIBILITIES; BLACK GRAIN EUMYCETOMA; MADURELLA-MYCETOMATIS; AMPHOTERICIN-B; RAVUCONAZOLE; ITRACONAZOLE; TERBINAFINE; SURVIVAL; TRIAZOLE; AZOLES;
D O I：
10.3389/fphar.2023.1165273
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Eumycetoma, a chronic subcutaneous mycosis, responds poorly to the available antifungal treatments and patients often require extensive surgical resection or amputation of the affected limb. More effective treatments are needed for eumycetoma. This article will describe some of the approaches being used to develop and evaluate new treatments for eumycetoma, summarise the latest developments and discuss the challenges that lie ahead.
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页数：11
相关论文
共 55 条
[1]   Development and Validation of an In Vitro Resazurin-Based Susceptibility Assay against Madurella mycetomatis [J].
Abd Algaffar, S. O. ;
Verbon, A. ;
van de Sande, W. W. J. ;
Khalid, S. A. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 65 (03)
[2]   A murine model of Madurella mycetomatis eumycetoma [J].
Ahmed, AO ;
van Vianen, W ;
ten Kate, MT ;
van de Sande, WWJ ;
van Belkum, A ;
Fahal, AH ;
Verbrugh, HA ;
Bakker-Woudenberg, IAJM .
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2003, 37 (01) :29-36
[3]   In vitro susceptibilities of Madurella mycetomatis to itraconazole and amphotericin B assessed by a modified NCCLS method and a viability-based 2,3-Bis(2-methoxy-4-nitro-5-[sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTT) assay [J].
Ahmed, AOA ;
van de Sande, WWJ ;
van Vianen, W ;
van Belkum, A ;
Fahal, AH ;
Verbrugh, HA ;
Bakker-Woudenberg, IAJM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (07) :2742-2746
[4]  
Ahmed SA., 2019, MANUAL CLIN MICROBIO, P2261
[5]   Nigrograna mackinnonii, Not Trematosphaeria grisea (syn., Madurella grisea), Is the Main Agent of Black Grain Eumycetoma in Latin America [J].
Ahmed, Sarah A. ;
Gonzalez, Gloria M. ;
Tirado-Sanchez, Andres ;
Miguel Moreno-Lopez, Luis ;
de Hoog, Sybren ;
Bonifaz, Alexandro .
JOURNAL OF CLINICAL MICROBIOLOGY, 2018, 56 (03)
[6]   In vitro antifungal susceptibility of coelomycete agents of black grain eumycetoma to eight antifungals [J].
Ahmed, Sarah Abdalla ;
de Hoog, G. Sybren ;
Stevens, David A. ;
Fahal, Ahmed H. ;
van de Sande, Wendy W. J. .
MEDICAL MYCOLOGY, 2015, 53 (03) :295-301
[7]   In Vitro Interaction of Currently Used Azoles with Terbinafine against Madurella mycetomatis [J].
Ahmed, Sarah Abdalla ;
Kloezen, Wendy ;
Fahal, Ahmed H. ;
de Hoog, G. Sybren ;
van de Sande, Wendy W. J. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (02) :1373-1374
[8]   Madurella mycetomatis Is Highly Susceptible to Ravuconazole [J].
Ahmed, Sarah Abdalla ;
Kloezen, Wendy ;
Duncanson, Frederick ;
Zijlstra, Ed E. ;
de Hoog, G. Sybren ;
Fahal, Ahmed H. ;
van de Sande, Wendy W. J. .
PLOS NEGLECTED TROPICAL DISEASES, 2014, 8 (06)
[9]  
Bakshi R, 2008, INDIAN J PATHOL MICR, V51, P154
[10]   In vitro activity of the novel antifungal compound F901318 against difficult-to-treat Aspergillus isolates [J].
Buil, J. B. ;
Rijs, A. J. M. M. ;
Meis, J. F. ;
Birch, M. ;
Law, D. ;
Melchers, W. J. G. ;
Verweij, P. E. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017, 72 (09) :2548-2552
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