A comprehensive overview of Artemisinin and its derivatives as anticancer agents

被引：46
作者：
Zeng, Zi-wei [1 ]
Chen, Di [1 ]
Chen, Lei [1 ]
He, Bin [1 ]
Li, Yan [1 ]
机构：
[1] Guizhou Med Univ, Engn Res Ctr Dev & Applicat Ethn Med & TCM, Sch Basic Med Sci, Sch Pharm,State Key Lab Funct & Applicat Medicinal, Guiyang 550004, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 247卷
基金：
中国国家自然科学基金;
关键词：
Artemisinin; Derivatives; Antimalarial; Anticancer; Mechanism; CELL-CYCLE ARREST; ADD-ON THERAPY; HYDROXY-FUNCTIONALIZED; 11-AZAARTEMISININS; METASTATIC BREAST-CANCER; HUMAN CERVICAL-CANCER; ANTITUMOR-ACTIVITY; IN-VITRO; ORAL ARTESUNATE; PHASE-I; DEPENDENT APOPTOSIS;
D O I：
10.1016/j.ejmech.2022.115000
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Artemisinin is the crucial ingredient of artemisia annua, a traditional Chinese medicine used for the therapy of malaria in China for hundreds of years. In recent years, the anticancer properties of artemisinin and its de-rivatives have also been reported. This review has summarized the research and development of artemisinin and its derivatives as anticancer agents, which included both natural and synthetic monomers as well as their dimers. In addition, it highlights the antitumor effects of artemisinin and its derivatives after site-modification or after transformation to a nano-delivery system. Moreover, we have further explored their potential mechanisms of action and also discussed the clinical trials of ARTs used to treat cancer, which will facilitate in further devel-opment of novel anticancer drugs based on the scaffold of artemisinin.
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页数：20
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