A comprehensive overview of Artemisinin and its derivatives as anticancer agents

被引：44
作者：
Zeng, Zi-wei [1 ]
Chen, Di [1 ]
Chen, Lei [1 ]
He, Bin [1 ]
Li, Yan [1 ]
机构：
[1] Guizhou Med Univ, Engn Res Ctr Dev & Applicat Ethn Med & TCM, Sch Basic Med Sci, Sch Pharm,State Key Lab Funct & Applicat Medicinal, Guiyang 550004, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 247卷
基金：
中国国家自然科学基金;
关键词：
Artemisinin; Derivatives; Antimalarial; Anticancer; Mechanism; CELL-CYCLE ARREST; ADD-ON THERAPY; HYDROXY-FUNCTIONALIZED; 11-AZAARTEMISININS; METASTATIC BREAST-CANCER; HUMAN CERVICAL-CANCER; ANTITUMOR-ACTIVITY; IN-VITRO; ORAL ARTESUNATE; PHASE-I; DEPENDENT APOPTOSIS;
D O I：
10.1016/j.ejmech.2022.115000
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Artemisinin is the crucial ingredient of artemisia annua, a traditional Chinese medicine used for the therapy of malaria in China for hundreds of years. In recent years, the anticancer properties of artemisinin and its de-rivatives have also been reported. This review has summarized the research and development of artemisinin and its derivatives as anticancer agents, which included both natural and synthetic monomers as well as their dimers. In addition, it highlights the antitumor effects of artemisinin and its derivatives after site-modification or after transformation to a nano-delivery system. Moreover, we have further explored their potential mechanisms of action and also discussed the clinical trials of ARTs used to treat cancer, which will facilitate in further devel-opment of novel anticancer drugs based on the scaffold of artemisinin.
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页数：20
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共 170 条
  • [31] Biodegradable iron-coordinated hollow polydopamine nanospheres for dihydroartemisinin delivery and selectively enhanced therapy in tumor cells
    Dong, Liang
    Wang, Chao
    Zhen, Wenyao
    Jia, Xiaodan
    An, Shangjie
    Xu, Zhiai
    Zhang, Wen
    Jiang, Xiue
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2019, 7 (40) : 6172 - 6180
  • [32] DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin
    Du, Jing
    Wang, Tongtong
    Li, Yanchun
    Zhou, Yi
    Wang, Xin
    Yu, Xingxing
    Ren, Xueying
    An, Yihan
    Wu, Yi
    Sun, Weidong
    Fan, Weimin
    Zhu, Qiaojuan
    Wang, Ying
    Tong, Xiangmin
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2019, 131 : 356 - 369
  • [33] Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin
    Du, Xiao-Xue
    Li, Yan-Jing
    Wu, Chun-Long
    Zhou, Jian-Hua
    Han, Yu
    Sui, Hong
    Wei, Xiao-Li
    Liu, Lei
    Huang, Peng
    Yuan, Heng-Heng
    Zhang, Ting-Ting
    Zhang, Wen-Jie
    Xie, Rui
    Lang, Xiao-Hui
    Jia, De-Xin
    Bai, Yu-Xian
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2013, 67 (05) : 417 - 424
  • [34] Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron
    Efferth, T
    Benakis, A
    Romero, MR
    Tomicic, M
    Rauh, R
    Steinbach, D
    Häfer, R
    Stamminger, T
    Oesch, F
    Kaina, B
    Marschall, M
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (07) : 998 - 1009
  • [35] Combination-treatment of glioblastoma multiforme cell lines with the anti-malarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774
    Efferth, T
    Ramirez, T
    Gebhart, E
    Halatsch, ME
    [J]. BIOCHEMICAL PHARMACOLOGY, 2004, 67 (09) : 1689 - 1700
  • [36] Molecular modes of action of artesunate in tumor cell lines
    Efferth, T
    Sauerbrey, A
    Olbrich, A
    Gebhart, E
    Rauch, P
    Weber, HO
    Hengstler, JG
    Halatsch, ME
    Volm, M
    Tew, KD
    Ross, DD
    Funk, JO
    [J]. MOLECULAR PHARMACOLOGY, 2003, 64 (02) : 382 - 394
  • [37] Cancer combination therapies with artemisinin-type drugs
    Efferth, Thomas
    [J]. BIOCHEMICAL PHARMACOLOGY, 2017, 139 : 56 - 70
  • [38] Eling Nils, 2015, Oncoscience, V2, P517
  • [39] Population pharmacokinetics of artesunate and dihydroartemisinin during long-term oral administration of artesunate to patients with metastatic breast cancer
    Ericsson, Therese
    Blank, Antje
    von Hagens, Cornelia
    Ashton, Michael
    Abelo, Angela
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 70 (12) : 1453 - 1463
  • [40] Antiplasmodial and antitumor activity of dihydroartemisinin analogs derived via the aza-Michael addition reaction
    Feng, Tzu-Shean
    Guantai, Eric M.
    Nell, Margo J.
    van Rensburg, Constance E. J.
    Hoppe, Heinrich C.
    Chibale, Kelly
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (10) : 2882 - 2886
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