Electrochemical oxidative carbonylation of hydrazides for the synthesis of 1,3,4-oxadiazole-2(3H)-ones

被引：5

作者：

Peng, Mengyu ^{[1
]}

Li, Mingzhe ^{[1
]}

Zhao, Longqiang ^{[1
]}

Huang, Wenxiu ^{[1
]}

Wang, Shoucai ^{[1
]}

Chen, Kang ^{[1
]}

Jiang, Guangbin ^{[1
]}

Ji, Fanghua ^{[1
]}

机构：

[1] Guilin Univ Technol, Guangxi Key Lab Elect & Magnetochem Funct Mat, Coll Chem & Bioengn, 12 Jiangan Rd, Guilin 541004, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 22期

基金：

中国国家自然科学基金;

关键词：

H/N-H CARBONYLATION; DERIVATIVES; ANALOGS; POTENT;

D O I：

10.1039/d3qo01338c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed an electrochemical method for the synthesis of 1,3,4-oxadiazole-2(3H)-ones using CO (carbon monoxide) as the carbonyl source under undivided electrolytic conditions. The electrochemical oxidative carbonylation of hydrazides features mild, green and external oxidant-free conditions, broad substrate scope, a short reaction time and ease of scale-up to the gram scale. Both control experiments and mechanistic studies revealed that no radical process was involved in this electrochemical transformation.

引用

页码：5680 / 5684

页数：5

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