Novel Insights into the Molecular Mechanisms of Atherosclerosis

被引:23
|
作者
Wojtasinska, Armanda [1 ]
Frak, Weronika [1 ]
Lisinska, Wiktoria [1 ]
Sapeda, Natalia [1 ]
Mlynarska, Ewelina [1 ]
Rysz, Jacek [2 ]
Franczyk, Beata [1 ]
机构
[1] Med Univ Lodz, Dept Nephrocardiol, Ul Zeromskiego 113, PL-90549 Lodz, Poland
[2] Med Univ Lodz, Dept Nephrol Hypertens & Family Med, Ul Zeromskiego 113, PL-90549 Lodz, Poland
关键词
atherosclerosis; cardiovascular diseases; inflammation; endothelial dysfunction; uric acid; vitamin D; miRNA expression; molecular mechanisms; VITAMIN-D DEFICIENCY; C-REACTIVE PROTEIN; ENDOTHELIAL DYSFUNCTION; URIC-ACID; CLONAL HEMATOPOIESIS; CARDIOVASCULAR-DISEASES; NLRP3; INFLAMMASOME; D SUPPLEMENTATION; PATHOBIOLOGY; MORTALITY;
D O I
10.3390/ijms241713434
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Atherosclerosis is one of the most fatal diseases in the world. The associated thickening of the arterial wall and its background and consequences make it a very composite disease entity with many mechanisms that lead to its creation. It is an active process, and scientists from various branches are engaged in research, including molecular biologists, cardiologists, and immunologists. This review summarizes the available information on the pathophysiological implications of atherosclerosis, focusing on endothelium dysfunction, inflammatory factors, aging, and uric acid, vitamin D, and miRNA expression as recent evidence of interactions of the molecular and cellular elements. Analyzing new discoveries for the underlying causes of this condition assists the general research to improve understanding of the mechanism of pathophysiology and thus prevention of cardiovascular diseases.
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收藏
页数:24
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