Protective Effect of Quercetin and Ginger (Zingiber officinale) Extract against Dimethoate Potentiated Fluoride-Induced Nephrotoxicity in Rats

被引：4
作者：
Sharma, Priyanka [1 ]
Verma, Pawan Kumar [1 ]
Sood, Shilpa [2 ]
Yousuf, Rasia [1 ]
Kumar, Amit [3 ]
Raina, Rajinder [1 ]
Shabbir, Muhammad Asim [4 ]
Bhat, Zuhaib F. [5 ]
机构：
[1] SKUAST Jammu, Fac Vet Sci & Anim Husb, Div Vet Pharmacol & Toxicol, Jammu 181102, India
[2] SKUAST Jammu, Fac Vet Sci & Anim Husb, Div Vet Pathol, Jammu 181102, India
[3] CSIR Lab, Indian Inst Integrat Med, Qual Management & Instrumentat Div, Jammu 180016, India
[4] Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad 38000, Pakistan
[5] SKUAST Jammu, Div Livestock Prod Technol, Jammu 181102, India
来源：
FOODS | 2023年 / 12卷 / 09期
关键词：
fluoride; dimethoate; nephrotoxicity; quercetin; Zingiber officinale; Wistar rats; OXIDATIVE STRESS; ANTIOXIDANT STATUS; ORAL-EXPOSURE; RENAL TISSUE; CHLORPYRIFOS; LIVER; SERUM; CALCIUM; PROTEIN; BRAIN;
D O I：
10.3390/foods12091899
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
This study aimed to determine the potential of quercetin and Zingiber officinale (ZO) Roscoe extract to alleviate the renal damage induced by dimethoate (DM) and fluoride (F-) alone and by their combined exposure in rats. A total of 54 adult Wistar rats were randomly allocated to nine groups (n = 6). A sub-lethal dose of DM (1/10th of the median lethal dose) was administered by oral gavage alone and along with F- (4.5 ppm, three-fold the permissible limit) in their drinking water continuously for 28 days. Chromatographical analysis revealed the presence of quercetin, curcumin, and other phytochemicals with strong antioxidant properties in ZO-rhizome extract. Severe changes were observed in the levels of the renal biomarkers and histoarchitecture after co-administration of the toxicants, indicating greater kidney damage. The administration of ZO extract (300 mg/kg) along with either or both toxicants led to a significant restoration of the biochemical markers and renal antioxidant profile and histology.
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页数：17
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