Increased risk of group B streptococcal sepsis and meningitis in HIV-exposed uninfected infants in a high-income country

被引：6

作者：

Manzanares, A. ^{[1
]}

Prieto-Tato, L. M. ^{[1
,2
,5
]}

Escosa-Garcia, L. ^{[3
]}

Navarro, M. ^{[2
,4
,5
,7
]}

Guillen, S. ^{[6
,7
]}

Penin, M. ^{[8
]}

Hernanz-Lobo, A. ^{[4
,7
]}

Soto-Sanchez, B. ^{[9
]}

Beceiro-Mosquera, J. ^{[10
]}

Falces-Romero, I ^{[11
]}

Ramos-Amador, J. T. ^{[5
,12
]}

Orellana-Miguel, M. A. ^{[13
]}

Epalza, C. ^{[1
,2
]}

机构：

[1] Hosp 12 Octubre Imas12, Inst Invest Sanitaria, Dept Pediat, Pediat Infect Dis Unit,Pediat Res & Clin Trials U, Madrid, Spain

[2] Translat Res Network Pediat Infect Dis RITIP, Madrid, Spain

[3] Inst Salud Carlos III, Hosp Univ Carlos III La Paz, Dept Pediat, Pediat Infect Dis Unit,CIBER Enfermedades Infecci, Madrid, Spain

[4] Hosp Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IiSGM, Dept Pediat, Pediat Infect Dis Unit, Madrid, Spain

[5] Univ Complutense Madrid, Madrid, Spain

[6] Hosp Getafe, Pediat Infect Dis Unit, Madrid, Spain

[7] Inst Salud Carlos III, CIBER Enfermedades Infecciosas CIBERINFEC, Madrid, Spain

[8] Hosp Univ Ppe Asturias, Dept Pediat, Madrid, Spain

[9] Hosp Getafe, Dept Pediat, Madrid, Spain

[10] Hosp Univ Ppe Asturias, Dept Neonatol, Madrid, Spain

[11] Inst Salud Carlos III, Hosp Univ La Paz, Microbiol & Parasitol Dept, CIBER Enfermedades Infecciosas CIBERINFEC, Madrid, Spain

[12] Univ Complutense, Inst Salud Carlos III, CIBER Enfermedades Infecciosas CIBERINFEC, Dept Paediat,Inst Invest Sanitaria Hosp Clin, Madrid, Spain

[13] Hosp Univ, Inst Invest Sanitaria Hosp, Dept Microbiol, 12 Octubre12 Octubre Imasl2, De Octubre12 De Octubre 12, Spain

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2023年 / 182卷 / 02期

关键词：

Neonatal sepsis; Group B Streptococcus; HIV-exposed uninfected; HIV-unexposed; GBS meningitis; CHILDREN; POPULATION;

D O I：

10.1007/s00431-022-04710-6

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The purpose of this study is to compare group B Streptococcus (GBS) infection incidence in HIV-exposed uninfected (HEU) and HIV-unexposed (HU) infants in a Spanish cohort. We conducted a retrospective study in 5 hospitals in Madrid (Spain). Infants <= 90 days of life with a GBS infection were included from January 2008 to December 2017. Incidence of GBS infection in HEU and HU children was compared. HEU infants presented a sevenfold greater risk of GBS infection and a 29-fold greater risk of GBS meningitis compared to HU, with statistical significance. Early-onset infection was tenfold more frequent in HEU children, with statistical significance, and late-onset infection was almost fivefold more frequent in the HUE infants' group, without statistical significance. Conclusion: HEU infants presented an increased risk of GBS sepsis and meningitis. One in each 500 HEU infants of our cohort had a central nervous system infection and 1 in each 200, a GBS infection. Although etiological causes are not well understood, this should be taken into account by physicians when attending this population.

引用

页码：575 / 579

页数：5

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