Comprehensive characterization of Fidgetin on tumor immune microenvironment evaluation and immunotherapy in human hepatocellular carcinoma

被引:0
作者
Qi, Longju [1 ,2 ]
Chen, Shiyuan [1 ]
Liao, Zehua [1 ]
Fan, Mengjie [1 ]
Zhang, Jiayi [1 ]
Gao, Yuan [1 ]
Shen, Jiabao [1 ]
Sun, Yuyu [2 ]
Wang, Qinghua [1 ]
机构
[1] Nantong Univ, Lab Anim Ctr, Sch Med, Nantong, Jiangsu, Peoples R China
[2] Nantong Hosp 3 Nantong Univ, Affiliated Nantong Hosp 3, Nantong, Peoples R China
来源
AGING-US | 2024年 / 16卷 / 05期
关键词
hepatocellular carcinoma; Fidgetin; immune checkpoint; prognosis; immune infiltration; PROGNOSTIC BIOMARKER; CANCER; PROGRESSION;
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Most cancers have a downregulation of Fidgetin (FIGN), which has been linked to tumor growth. However, there aren't many papers that mention FIGN's connection to hepatocellular carcinoma (HCC). Here, FIGN expression in HCC tissues was markedly reduced as compared to nearby normal liver tissues. According to univariate and multivariate Cox regression, it served as an independent predictor of survival outcomes. Patients with high levels of FIGN expression had a worse outcome. FIGN was shown to be engaged in immune -related pathways and to have a positive correlation with immunological score and immune cells according to KEGG pathway analysis. In HCC patients, FIGN was substantially linked with immunological checkpoints and the hot tumor state. Additionally, immunotherapy and chemotherapy showed a significant therapeutic response in HCC patients with low FIGN expression. This research revealed that FIGN expression was tightly related to hepatoma immunity and might be employed as a biomarker to predict patient prognosis and guide medication.
引用
收藏
页码:4445 / 4468
页数:24
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