Does the Impact of COVID-19 on Patients With Systemic Sclerosis Change Over Time?

被引：1

作者：

Deibel, Elisabeth ^{[1
]}

Carreira, Patricia E. ^{[2
]}

Vonk, Madelon ^{[3
]}

del Papa, Nicoletta ^{[4
]}

Becvar, Radim ^{[5
]}

Guillen-Del-Castillo, Alfredo ^{[6
]}

Campochiaro, Corrado ^{[7
]}

Poormoghim, Hadi ^{[8
]}

Liem, Sophie ^{[9
]}

Lazzaroni, Maria-Grazia ^{[10
]}

Giollo, Alessandro ^{[11
]}

Mekinian, Arsene ^{[12
]}

de Vries-Bouwstra, Jeska ^{[9
]}

De Santis, Maria ^{[13
,14
]}

Balbir-Gurman, Alexandra ^{[15
,16
]}

Mihai, Carina ^{[1
]}

De Luca, Giacomo ^{[7
]}

Moiseev, Sergey ^{[17
]}

Zanatta, Elisabetta ^{[18
]}

Foti, Rosario ^{[19
]}

Rednic, Simona ^{[20
]}

Denton, Christopher ^{[21
]}

Cutolo, Maurizio ^{[22
]}

Belloli, Laura ^{[23
]}

Airo, Paolo ^{[10
]}

Garzanova, Liudmila ^{[24
]}

Moroncini, Gianluca ^{[25
]}

Inanc, Murat ^{[26
]}

Panopoulos, Stylianos ^{[27
]}

Tandaipan, Jose-Luis ^{[28
]}

Chatelus, Emmanuel ^{[29
]}

Rosato, Edoardo ^{[30
]}

Kuwana, Masataka ^{[31
]}

Yavuz, Sule ^{[32
]}

Alegre-Sancho, Juan J. ^{[33
]}

Smith, Vanessa ^{[34
,35
,36
]}

Szucs, Gabriella ^{[37
]}

Henes, Joerg ^{[38
]}

Rodriguez-Pinto, Ignasi ^{[39
]}

Atzeni, Fabiola ^{[40
]}

Spierings, Julia ^{[41
]}

Truchetet, Marie-Elise ^{[42
]}

Milchert, Marcin ^{[43
]}

de Araujo, Daniel Brito ^{[41
,44
]}

Riemekasten, Gabriela ^{[45
]}

Bernardino, Vera ^{[46
]}

Martin, Thierry ^{[47
]}

del Galdo, Francesco ^{[48
,49
]}

Vacca, Alessandra ^{[50
]}

Mendoza, Fabian ^{[51
]}

机构：

[1] Univ Zurich, Univ Hosp Zurich, Zurich, Switzerland

[2] 12 Octubre Univ Hosp, Madrid, Spain

[3] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands

[4] Univ Milan, ASST G Pini CTO, Milan, Italy

[5] Charles Univ Prague, Med Sch 1, Prague, Czech Republic

[6] Hosp Univ Vall dHebron, Barcelona, Spain

[7] Osped San Raffaele, IRCCS, Milan, Italy

[8] Firoozgar Hosp, Tehran, Iran

[9] Leiden Univ, Med Ctr, Leiden, Netherlands

[10] Univ Brescia, ASST Spedali Civili Brescia, Brescia, Italy

[11] Univ Verona, Verona, Italy

[12] Hop St Antoine, Paris, France

[13] Humanitas Res Hosp, IRCCS, Milan, Italy

[14] Humanitas Univ, Milan, Italy

[15] B Shine Rheumatol Inst, Haifa, Israel

[16] Technion, Haifa, Israel

[17] Sechenov First Moscow State Med Univ, Moscow, Russia

[18] Univ Padua, Padua, Italy

[19] AOU Policlin S Marco Catania, Catania, Italy

[20] Univ Med & Pharm Iuliu Hatieganu, Cluj Napoca, Romania

[21] Royal Free & Univ Coll London Med Sch, London, England

[22] Univ Genoa, Genoa, Italy

[23] ASST Grande Osped Metropolitano Niguarda, Milan, Italy

[24] VA Nasonova Res Inst Rheumatol, Moscow, Russia

[25] Univ Ancona, Univ Politecn Marche, Polo Didatt, Ancona, Italy

[26] Istanbul Univ, Istanbul, Turkiye

[27] Natl & Kapodistrian Univ Athens, Med Sch, Athens, Greece

[28] Hosp Univ Santa Creu & St Pau, Barcelona, Spain

[29] Ctr Natl Reference Malad Autoimmunes & Syst Rares, Strasbourg, France

[30] Sapienza Univ Rome, Rome, Italy

[31] Nippon Med Sch, Tokyo, Japan

[32] Univ Marmara, Istanbul, Turkiye

[33] Hosp Univ Dr Peset, Comunitat Valenciana, Valencia, Spain

[34] Univ Ghent, Ghent, Belgium

[35] Ghent Univ Hosp, Ghent, Belgium

[36] VIB Inflammat Res Ctr IRC, Ghent, Belgium

[37] Univ Debrecen, Debrecen, Hungary

[38] Univ Hosp Tuebingen, Ctr Interdisciplinary Clin Immunol Rheumatol & Au, Tubingen, Germany

[39] Hosp Univ Mutua Terrassa, Barcelona, Catalonia, Spain

[40] Univ Messina, Messina, Italy

[41] Univ Med Ctr Utrecht, Utrecht, Netherlands

[42] Univ Bordeaux, Bordeaux, Aquitaine, France

[43] Pomeranian Med Univ, Szczecin, Poland

[44] Univ Fed Pelotas, Pelotas, RS, Brazil

[45] Univ Lubeck, Univ Clin Schleswig Holstein, Lubeck, Germany

[46] Ctr Hosp Univ Lisboa Cent, Lisbon, Portugal

[47] Nouvel Hop Civil, Ctr Natl Reference Malad Autoimmunes & Syst Rares, Strasbourg, France

[48] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England

[49] Univ Leeds, NIHR Biomed Res Ctr, Leeds, W Yorkshire, England

[50] Azienda Osped Univ Cagliari, Cagliari, Italy

来源：

ARTHRITIS CARE & RESEARCH | 2024年 / 76卷 / 01期

关键词：

D O I：

10.1002/acr.25226

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. The outcome of patients with COVID-19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID-19 over several waves.Methods. Patients with both SSc and COVID-19 who were registered in the European Scleroderma Trials and Research group (EUSTAR) were collected between April 2020 and April 2021. Patients were assigned to waves 1, 2, or 3 depending on the date of their COVID-19 diagnosis. Primary endpoints were death, intensive care unit stay, or ventilatory support (severe outcome). Subgroup analyses of patients who were hospitalized or died were conducted. General and SSc-specific characteristics and treatment were compared over the waves. Descriptive statistics and multivariate logistic regression were applied.Results. A total of 333 patients were included; 57 patients (17%) had a severe outcome, and 30 patients (9%) died. Compared to wave 1, significantly fewer patients with SSc suffered from severe COVID-19 in waves 2 and 3 (28.2% vs 9.8% and 12.7%; P < 0.001), fewer patients required hospitalization (46.7% vs 19.6% and 25.5%; P < 0.001) or ventilatory support (24.0% vs 8.7% and 10.9%; P = 0.001), and fewer patients died (15.7% vs 5.0% and 7.5%; P = 0.011). Patients were significantly younger, more often men, had less frequent arterial hypertension, and less SSc cardiac involvement over waves 1 to 3. Patients received significantly less medium to high doses of corticosteroids as they did SSc treatment.Conclusion. The outcome of patients with both SSc and COVID-19 improved significantly over time because of intrinsic and extrinsic factors.

引用

页码：88 / 97

页数：10

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