Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy

被引：5

作者：

Amali, Aseervatham Anusha ^{[1
]}

Ravikumar, Sharada ^{[1
]}

Chew, Wei Leong ^{[2
,3
]}

Tan, Zhaohong ^{[1
]}

Sam, Qi Hui ^{[1
,3
]}

Chen, Kaiwen W. ^{[4
,5
]}

Boucher, Dave ^{[6
]}

MacLaren, Graeme ^{[7
,8
]}

Chai, Louis Yi Ann ^{[1
,3
,9
]}

机构：

[1] Natl Univ Hlth Syst, Dept Med, Div Infect Dis, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore

[2] Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

[3] Natl Univ Singapore, Synthet Biol Clin & Technol Innovat, Singapore, Singapore

[4] Natl Univ Singapore, Life Sci Inst, Immunol Programme, Singapore, Singapore

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Immunol Translat Res Programme, Singapore, Singapore

[6] Univ York, York Biomed Res Inst, Dept Biol, York, England

[7] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore, Singapore

[8] Natl Univ Singapore Hosp, Natl Univ Heart Ctr, Cardiothorac Intens Care Unit, Singapore, Singapore

[9] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore

来源：

CLINICAL INFECTIOUS DISEASES | 2024年 / 78卷 / 01期

关键词：

Burkholderia pseudomallei; extracorporeal membrane oxygenation; exome sequencing; inflammasome; immunotherapy; INFLAMMATORY CASPASES; GASDERMIN D; ACTIVATION; GSDMD;

D O I：

10.1093/cid/ciad517

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei infection, and how targeted adjunctive biological therapy led to a successful outcome.

引用

页码：94 / 97

页数：4

共 16 条

[1]

Benoit TJ, 2015, MMWR SURVEILL SUMM, V64, P1

[2] The protein structures that shape caspase activity, specificity, activation and inhibition [J].

Fuentes-Prior, P ;

Salvesen, GS .

BIOCHEMICAL JOURNAL, 2004, 384 :201-232

[3] Programmed cell death as a defence against infection [J].

Jorgensen, Ine ;

Rayamajhi, Manira ;

Miao, Edward A. .

NATURE REVIEWS IMMUNOLOGY, 2017, 17 (03) :151-164

[4] Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling [J].

Kayagaki, Nobuhiko ;

Stowe, Irma B. ;

Lee, Bettina L. ;

O'Rourke, Karen ;

Anderson, Keith ;

Warming, Soren ;

Cuellar, Trinna ;

Haley, Benjamin ;

Roose-Girma, Merone ;

Phung, Qui T. ;

Liu, Peter S. ;

Lill, Jennie R. ;

Li, Hong ;

Wu, Jiansheng ;

Kummerfeld, Sarah ;

Zhang, Juan ;

Lee, Wyne P. ;

Snipas, Scott J. ;

Salvesen, Guy S. ;

Morris, Lucy X. ;

Fitzgerald, Linda ;

Zhang, Yafei ;

Bertram, Edward M. ;

Goodnow, Christopher C. ;

Dixit, Vishva M. .

NATURE, 2015, 526 (7575) :666-671

[5] Autoantibodies against cytokines: phenocopies of primary immunodeficiencies? [J].

Ku, Chen-Lung ;

Chi, Chih-Yu ;

von Bernuth, Horst ;

Doffinger, Rainer .

HUMAN GENETICS, 2020, 139 (6-7) :783-794

[6] Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage [J].

Liu, Zhonghua ;

Wang, Chuanping ;

Yang, Jie ;

Chen, Yinghua ;

Zhou, Bowen ;

Abbott, Derek W. ;

Xiao, Tsan Sam .

IMMUNITY, 2020, 53 (01) :106-+

[7] Melioidosis, Singapore, 2003-2014 [J].

Pang, Long ;

Harris, Patrick N. A. ;

Seiler, Rachel L. ;

Ooi, Peng Lim ;

Cutter, Jeffrey ;

Goh, Kee Tai ;

Cook, Alex R. ;

Fisher, Dale ;

Chai, Louis Yi Ann .

EMERGING INFECTIOUS DISEASES, 2018, 24 (01) :140-143

[8] Immunotherapy Markedly Increases the Effectiveness of Antimicrobial Therapy for Treatment of Burkholderia pseudomallei Infection [J].

Propst, Katie L. ;

Troyer, Ryan M. ;

Kellihan, Lisa M. ;

Schweizer, Herbert P. ;

Dow, Steven W. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (05) :1785-1792

[9] Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes [J].

Ross, Connie ;

Chan, Amy H. ;

von Pein, Jessica B. ;

Maddugoda, Madhavi P. ;

Boucher, Dave ;

Schroder, Kate .

ANNUAL REVIEW OF IMMUNOLOGY, 2022, 40 :249-269

[10] Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death [J].

Shi, Jianjin ;

Zhao, Yue ;

Wang, Kun ;

Shi, Xuyan ;

Wang, Yue ;

Huang, Huanwei ;

Zhuang, Yinghua ;

Cai, Tao ;

Wang, Fengchao ;

Shao, Feng .

NATURE, 2015, 526 (7575) :660-665

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