SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer

被引：16

作者：

Li, Xiaoyue ^{[1
]}

Luo, Jing ^{[2
]}

Mou, Kelin ^{[1
]}

Peng, Lin ^{[3
]}

Zhou, Huan ^{[1
]}

Lei, Yulin ^{[1
]}

Wang, Huan ^{[1
]}

Zhao, Zhengfei ^{[4
]}

Wang, Jianmei ^{[5
]}

Wu, Jianhua ^{[6
]}

Wan, Runlan ^{[1
]}

Lin, Sheng ^{[1
]}

Xiang, Li ^{[1
,7
,8
]}

Luo, Yuhao ^{[1
,8
]}

机构：

[1] Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou 644000, Sichuan, Peoples R China

[2] Southwest Med Univ, Affiliated Hosp, Dept Cardiovasc Med, Luzhou, Sichuan, Peoples R China

[3] Southwest Med Univ, Affiliated Hosp, Dept Bone & Joint, Luzhou, Peoples R China

[4] Southwest Med Univ, Affiliated Hosp, Dept Gastrointestinal Surg, Luzhou, Sichuan, Peoples R China

[5] Southwest Med Univ, Affiliated Hosp, Dept Pathol, Luzhou, Peoples R China

[6] Southern Med Univ, Nanfang Hosp, Dept Oncol, Guangzhou 510000, Peoples R China

[7] Nucl Med & Mol Imaging Key Lab Sichuan Prov, Luzhou, Peoples R China

[8] Southwest Med Univ, Affiliated Hosp, Sichuan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2023年 / 19卷 / 10期

基金：

中国国家自然科学基金;

关键词：

TGF-beta; SDPR; CPT1A; fatty acid oxidation; gastric cancer; BREAST-CANCER; COLORECTAL-CANCER; PPAR-ALPHA; CELLS;

D O I：

10.7150/ijbs.83012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our previous studies have confirmed that transforming growth factor-beta (TGF-beta) plays an important role in tumor metastasis, and the serum deprivation protein response (SDPR) is a potential downstream target of TGF-beta. However, the role and mechanism of SDPR in gastric cancer are still unclear. We performed gene microarray, bioinformation analysis, combined with in vivo and in vitro experimental verification, we identified that SDPR is significantly downregulated in gastric cancer, and participates in TGF-beta-mediated tumour metastasis. Mechanically, SDPR interacts with extracellular signal-regulated kinase (ERK) and inhibits fatty acid metabolism key gene Carnitine palmitoyl transferase 1A (CPT1A) at transcriptional level by supressing ERK/PPAR pathway. Our findings suggest that the TGF-beta/SDPR/CPT1A axis play an important role in the fatty acid oxidation of gastric cancer, and provides a new insight into the crosstalk of tumour microenvironments and metabolism reprogramming and suggest that strategies to intervene the fatty acid metabolism may therapy gastric cancer metastasis.

引用

页码：2999 / 3014

页数：16

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