Synthesis of Some New Substituted Dihydro-5-(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazole) Heterocyclic Derivatives and Evaluation of Their Pharmacological Activities

A simple and efficient approach for the synthesis of dihydro-5-(4,5-dihydro-3-methyl-5-oxo-1phenyl-1H-pyrazole) heterocyclic derivatives was developed via Knoevenagel condensation reaction followed by Michael addition using L-proline as catalyst. The newly synthesized compounds were evaluated for anti-TB and in vitro cytotoxicity (MDA MB 231) for pharmacological investigations. Further, in silico molecular docking studies were carried out against PDB: 4BFT (anti-TB) and PDB: 6VJ3 (cytotoxicity) protein receptors. The outcome of pharmacological studies suggests that compounds can be used as potential materials in pharmaceutical chemistry.