Rhodium-Catalyzed Allylic C-H Functionalization of Unactivated Alkenes with ?-Diazocarbonyl Compounds

被引：14

作者：

Sihag, Pinki ^{[1
]}

Chakraborty, Trisha ^{[1
]}

Jeganmohan, Masilamani ^{[1
]}

机构：

[1] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India

来源：

ORGANIC LETTERS | 2023年

关键词：

DIAZO-COMPOUNDS; CROSS-COUPLINGS; CYCLOPROPANATION; ACTIVATION; INSERTION; OLEFINS; AMIDES; BONDS;

D O I：

10.1021/acs.orglett.2c04356

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A redox-neutral mild methodology for the allylic C-H alkylation of unactivated alkenes with diazo compounds is demonstrated. The developed protocol is able to bypass the possibility of the cyclopropanation of an alkene upon its reaction with the acceptor-acceptor diazo compounds. The protocol is highly accomplished due to its compatibility with various unactivated alkenes functionalized with different sensitive functional groups. A rhodacycle pi-allyl intermediate has been synthesized and proved to be the active intermediate. Additional mechanistic investigations aided the elucidation of the plausible reaction mechanism.

引用

页码：1257 / 1262

页数：6

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