Trismus, health-related quality of life, and trismus-related symptoms up to 5 years post-radiotherapy for head and neck cancer treated between 2007 and 2012

被引:16
作者
Aghajanzadeh, Susan [1 ,2 ]
Karlsson, Therese [1 ,2 ]
Tuomi, Lisa [2 ,3 ]
Engstrom, My [4 ,5 ]
Finizia, Caterina [1 ,2 ]
机构
[1] Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Otorhinolaryngol Head & Neck Surg, Gothenburg, Sweden
[2] Sahlgrens Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Gothenburg, Reg Vastra Gota, Sweden
[3] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Speech & Language Pathol Unit, Gothenburg, Sweden
[4] Univ Gothenburg, Inst Hlth & Care Sci, Sahlgrenska Acad, Gothenburg, Sweden
[5] Sahlgrens Univ Hosp, Dept Surg, Gothenburg, Reg Vastra Gota, Sweden
关键词
Trismus; Radiotherapy; Health-related quality of life; Mouth opening ability; Head and neck cancer; EUROPEAN-ORGANIZATION; IMPACT; QUESTIONNAIRE; COMORBIDITY; VALIDATION;
D O I
10.1007/s00520-023-07605-w
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PurposeRadiotherapy-induced trismus is present in up to 40% of patients treated radiotherapeutically for head and neck cancer (HNC) and impacts health-related quality of life (HRQL) negatively. This prospective study aimed to investigate the development of trismus and its influence on HRQL and trismus-related symptoms in HNC patients for up to 5 years post-radiotherapy completion as no such follow-up studies exist.MethodsPatients (n = 211) were followed prospectively from pre-radiotherapy to 12 and 60 months post-radiotherapy. At each follow-up, maximum interincisal opening (MIO) was measured, and patients filled in the European Organization for Treatment of Cancer Quality-of-Life Questionnaire Core-30 (EORTC QLQ-C30), Head and Neck-35 (EORTC QLQ-HN35), and Gothenburg Trismus Questionnaire (GTQ). Trismus was defined as an MIO <= 35 mm.ResultsAt 1 year post-radiotherapy, a total of 27% met the trismus criterion, and at 5 years post-radiotherapy, the corresponding figure was 28%. Patients in the trismus group scored significantly worse compared to the patients without trismus on 8/15 domains at 1 year post-radiotherapy on EORTC QLQ-C30, further worsening in 11/15 domains at 5 years post-radiotherapy. Similar results were found for EORTC QLQ-HN35. Patients with trismus reported more trismus-related symptoms according to the GTQ at both timepoints compared to those without trismus.ConclusionThis study highlights that HNC patients suffering from radiotherapy-induced trismus report poorer HRQL and more trismus-specific symptoms compared to patients without trismus. These differences persist and increase up to at least 5 years following treatment completion. Hence, our results highlight that radiotherapy-induced trismus affects long-term HRQL, jaw symptoms, and pain, further stressing the need for early and structured intervention.
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页数:9
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