Sensitive and Rapid Detection of Aspartic Acid with Co3O4-ZnO Nanorods Using Differential Pulse Voltammetry

被引：11
作者：
Alfaifi, Sulaiman Y. [1 ]
Adeosun, Waheed Abiodun [1 ,2 ]
Asiri, Abdullah M. [1 ,2 ]
Rahman, Mohammed M. [1 ,2 ]
机构：
[1] King Abdulaziz Univ, Fac Sci, Chem Dept, POB 80203, Jeddah 21589, Saudi Arabia
[2] King Abdulaziz Univ, Ctr Excellence Adv Mat Res CEAMR, POB 80203, Jeddah 21589, Saudi Arabia
来源：
BIOSENSORS-BASEL | 2023年 / 13卷 / 01期
关键词：
Co3O4-ZnO nanorods; aspartic acid; electrochemical method; sensitivity; healthcare safety; GLUTAMIC-ACID; AMINO-ACIDS; URIC-ACID; ASCORBIC-ACID; SENSOR; NANOPARTICLES; COMPOSITE; HETEROSTRUCTURE; NANOCOMPOSITES; CHROMATOGRAPHY;
D O I：
10.3390/bios13010088
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Herein, the detection of aspartic acid by doped Co3O4-ZnO nanorod materials was proposed using differential pulse voltammetry. The nano-composite metal oxide was synthesized by the wet precipitation method in basic media. Aspartic acid is a non-essential amino acid naturally synthesized in the body with lot of health significance, including as a biomarker for several health deficiencies. The synthesized composite Co3O4-ZnO nanorod was well-investigated by using FESEM, XRD, XPS, FTIR, UV/vis., EIS, and CV. The synthesized composite exhibited a low limit of detection (0.03 mu M, high sensitivity (0.0014 mu A mu M-1 cm(-2)) and wide linear range (0.05-50 mu M) for aspartic acid. The substrate, the Co3O4-ZnO nanorod, enhanced the electro-catalytic oxidation of aspartic acid as a result of its catalytic and conductivity properties. The developed sensor based on Co3O4-ZnO has a repeatable, reproducible and stable current response for aspartic acid. Additionally, other electroactive compounds did not interfere with the sensor's current response. The suitability of the developed sensor for real sample analysis was also established. Therefore, this study proposed the potential use of Co3O4-ZnO nanorod material in healthcare management for the maintenance of human well-being.
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页数：13
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