Morphological analysis of isolated hemivertebra: radiographic manifestations related to the severity of congenital scoliosis

Purpose The natural history of congenital scoliosis (CS) caused by hemivertebra varies greatly. This study aimed to explore the association between the morphology of hemivertebra and the severity of CS, since the diagnosis of the hemivertebra. Methods Patients with isolated (single fully segmented) hemivertebra were enrolled. The degree and progression of deformity were compared by three morphological parameters of hemivertebra, comprising whether the width of hemivertebra extends across the central vertical line of lower adjacent vertebra (midline); the lateral height ratio (LHR, lateral height of hemivertebrax 2/(lateral height of HV-1 plus HV + 1) with the cut-point being 0.9; and the sagittal position of hemivertebra that was divided into the lateral and posterolateral group. Results In total, 156 patients (mean age 9.7 +/- 6.2 years, 81 males) were enrolled. The number of thoracic, thoracolumbar (T12/13-L1), and lumbar hemivertebrae were 63, 41, and 52, respectively. Hemivertebrae across the midline had larger scoliosis and kyphosis (58.3 +/- 20.6(degrees) vs. 42.8 +/- 15.0(degrees), P < 0.001; 45.1 +/- 32.5(degrees) vs. 29.5 +/- 25.7(degrees), P = 0.013, respectively). Hemivertebrae with LHR >= 0.9 was associated with larger scoliosis (55.7 +/- 20.6(degrees) vs. 41.4 +/- 13.3(degrees), P < 0.001). Larger scoliosis and kyphosis were observed in posterolateral hemivertebrae (54.4 +/- 21.0(degrees) vs. 44.4 +/-; 15.6(degrees), P = 0.026; 51.4 +/- 31.5(degrees) vs. 20.6 +/- 17.1(degrees), P < 0.001, respectively). Co-occurrence of more than one of the three positive parameters above indicated higher annual progression (5.0 +/- 2.2(degrees) vs. 3.3 +/- 1.3(degrees), P < 0.001). Conclusion Three positive parameters, width across the midline, LHR >= 0.9, and posterolateral position were associated with a more severe deformity in patients with isolated hemivertebra. Hemivertebrae with more than one positive parameter may cause progressive deformity, and thus need prompt surgery. Level of evidence Prognostic, level IV.