Diabetes and cognitive decline: Challenges and future direction

被引：13
作者：
Ab-Hamid, Norhamidar [1 ]
Omar, Norsuhana [2 ]
Ismail, Che Aishah Nazariah [2 ]
Long, Idris [1 ,3 ]
机构：
[1] Univ Sains Malaysia, Sch Hlth Sci, Biomed Program, Hlth Campus, Kota Baharu 16150, Kelantan, Malaysia
[2] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Hlth Campus, Kota Baharu 16150, Kelantan, Malaysia
[3] Univ Sains Malaysia, Sch Hlth Sci, Biomed Program, Hlth Campus,Jalan Hosp USM, Kota Baharu 16150, Kelantan, Malaysia
来源：
WORLD JOURNAL OF DIABETES | 2023年 / 14卷 / 06期
关键词：
Diabetes mellitus; Insulin signaling; Macrovascular disease; Microvascular disease; Animal models; Cognitive decline; Pathophysiology; OBESE ZUCKER RATS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; INSULIN-RESISTANCE; MEMORY IMPAIRMENT; SEVERE HYPOGLYCEMIA; SPATIAL MEMORY; OLDER-ADULTS; RISK-FACTORS; TYPE-2;
D O I：
10.4239/wjd.v14.i6.795
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
There is growing evidence that diabetes can induce cognitive decline and dementia. It is a slow, progressive cognitive decline that can occur in any age group, but is seen more frequently in older individuals. Symptoms related to cognitive decline are worsened by chronic metabolic syndrome. Animal models are frequently utilized to elucidate the mechanisms of cognitive decline in diabetes and to assess potential drugs for therapy and prevention. This review addresses the common factors and pathophysiology involved in diabetes-related cognitive decline and outlines the various animal models used to study this condition.
引用
收藏
页码：795 / 807
页数：13
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