Melatonin inhibited the progression of gastric cancer induced by Bisphenol S via regulating the estrogen receptor 1

被引：12
作者：
Wang, Yi [1 ]
Song, Jintian [2 ]
Li, Yangming [1 ]
Lin, Chen [3 ]
Chen, Yan [3 ]
Zhang, Xu [4 ]
Yu, Hui [5 ]
机构：
[1] Fujian Med Univ, Fujian Canc Hosp, Dept Gastrointestinal Surg Oncol, Clin Oncol Sch, Fuzhou 350000, Fujian, Peoples R China
[2] Fujian Med Univ, Fujian Canc Hosp, Dept Abdominal Oncol, Clin Oncol Sch, Fuzhou 350000, Fujian, Peoples R China
[3] Fujian Med Univ, Sch Pharm, Fuzhou 350000, Fujian, Peoples R China
[4] Nanjing Med Univ, Nanjing 210029, Peoples R China
[5] Fujian Med Univ, Fujian Canc Hosp, Dept Pharm, Clin Oncol Sch, Fuzhou 350000, Fujian, Peoples R China
来源：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2023年 / 259卷
关键词：
ESR1; Gastric cancer; Bisphenol S; Melatonin; Molecular docking; IN-VITRO; EPIDEMIOLOGY; APOPTOSIS;
D O I：
10.1016/j.ecoenv.2023.115054
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
In recent years, Bisphenol S (BPS) has increasingly been used as an alternative to Bisphenol A (BPA) in food, paper, and personal care products. It is imperative to clarify the relationship between BPS and tumors in order to treat and prevent diseases. This study discovered a new method for predicting tumor correlations between BPS interactive genes. According to analyses conducted by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes, interactive genes were primarily found in gastric cancer. Based on gene-targeted prediction and molecular docking, BPS appears to exert potential gastric cancer-causing effects through estrogen receptor 1 (ESR1). In addition, gastric cancer patients' prognosis could be accurately predicted by a bisphenol-based prognostic prediction model. Subsequently, the proliferation and migration abilities of gastric cancer cells were further demonstrated to be significantly enhanced by BPS. Similarly, molecular docking analysis revealed that melatonin is also highly correlated with gastric cancer and BPS. In cell proliferation and migration assays, melatonin and BPS exposure inhibited the invasion abilities of gastric cancer cells compared to BPS-exposure. Our research provided a new direction for the exploration the correlation between cancer and environmental toxicity.
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页数：20
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