From worms to humans: Understanding intestinal lipid metabolism via model organisms

被引：12

作者：

Kozan, Darby W. ^{[1
,2
]}

Derrick, Joshua T. ^{[1
,2
]}

Ludington, William B. ^{[1
,2
]}

Farber, Steven A. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Dept Biol, Baltimore, MD USA

[2] Carnegie Inst Sci, Dept Embryol, Baltimore, MD USA

[3] Carnegie Inst Sci, Dept Embryol, 3520 San Martin Dr, Baltimore, MD 21218 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2023年 / 1868卷 / 04期

关键词：

Intestine; Lipids; Fatty acid; Apolipoprotein B; Chylomicron; Metabolic disease; Model organism; Zebrafish; Drosophila; APOLIPOPROTEIN-A-IV; FATTY-ACID-COMPOSITION; TRIGLYCERIDE TRANSFER PROTEIN; ELEMENT-BINDING PROTEIN-1; GLUCAGON-LIKE PEPTIDE-1; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; MEDIUM-CHAIN; POSTPRANDIAL DYSLIPIDEMIA; LIPOPROTEIN METABOLISM;

D O I：

10.1016/j.bbalip.2023.159290

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intestine is responsible for efficient absorption and packaging of dietary lipids before they enter the circu-latory system. This review provides a comprehensive overview of how intestinal enterocytes from diverse model organisms absorb dietary lipid and subsequently secrete the largest class of lipoproteins (chylomicrons) to meet the unique needs of each animal. We discuss the putative relationship between diet and metabolic disease progression, specifically Type 2 Diabetes Mellitus. Understanding the molecular response of intestinal cells to dietary lipid has the potential to undercover novel therapies to combat metabolic syndrome.

引用

页数：15

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