Open Latin American anaphylaxis registry

被引：14

作者：

Jares, Edgardo J. ^{[1
,25
]}

Cardona, Victoria ^{[2
]}

Gome, R. Maximiliano ^{[3
]}

Bernstein, Jonathan A. ^{[4
]}

Filho, Nelson A. Rosario ^{[5
]}

Cherrez-Ojeda, Ivan ^{[6
]}

Ensina, Luis Felipe ^{[7
]}

De Falco, Alicia ^{[8
]}

Diaz, Maria C. ^{[9
]}

Vereau, Pierre A. Chavez ^{[10
]}

Felix, Mara M. Rocha ^{[11
]}

Lavrut, Jorge ^{[9
]}

Laflor, Oscar I. Moreno ^{[12
]}

Staffeld, Patricia Latour ^{[13
]}

Piraino, Pedro ^{[14
]}

Duarte, Perla Alacaraz ^{[15
]}

Ivancevich, Juan C. ^{[16
]}

Dabove, Fabian ^{[17
]}

Giavina-Bianchi, Pedro ^{[18
]}

Moran, Ivan O. Tinoco ^{[19
]}

Oliviera, Fabiana A. Nunes ^{[20
]}

Monsell, Silvana ^{[21
]}

V. Souza, Maria ^{[9
]}

Cepeda, Alfonso M. ^{[22
]}

Slullitel, Pablo D. ^{[23
]}

Morfin-Maciel, Blanca M. ^{[24
]}

机构：

[1] CMP SA LIBRA Fdn, Allergy Sect, Buenos Aires, Argentina

[2] Hosp Universitari Vall Dhebron, Allergy Sect, Barcelona, Spain

[3] Catholic Univ Salta, Sch Hlth Sci, Salta, Argentina

[4] Univ Cincinnati, Dept Internal Med, Div Rheumatol Allergy & Immunol Cincinnati, Med, Cincinnati, OH USA

[5] Univ Fed Parana, Pediat, Curitiba, Brazil

[6] Univ Espiritu Santo, Respiralab Res Ctr, Samborondon, Ecuador

[7] Univ Fed Sao Paulo, Dept Pediat, Faaaai Affiliate Preceptor & Res Associate Div All, Sao Paulo, Brazil

[8] Univ Nacl La Plata, Hosp Espanol La Plata, Fac Cs Med, Dto Posgrad,Area Alergia & Inmunol Clin, La Plata, Argentina

[9] Hosp Pedro Elizalde, Buenos Aires, Argentina

[10] Univ Peruana Ciencias Aplicadas, Clin Int, Lima, Peru

[11] Univ Fed Estado Rio De Janeiro, Allergy & Immunol, Rio De Janeiro, Brazil

[12] Hosp Infantil Mexico Dr Federico Gomez, Allergy & Clin Immunol Dept, Mexico City, Mexico

[13] Univ Nacl Pedro Henriquez Urena, Ctr Avanzado Alergia & Asma, Santo Domingo, Dominican Rep

[14] Univ Catolica Ntra Senora De La Asuncion, Asuncion, Paraguay

[15] Univ Nacl Asuncion, Asuncion, Paraguay

[16] Univ Salvador, Fac Med, Immunol, Buenos Aires, Argentina

[17] Cemlo Res Ctr Director, Lobos, Argentina

[18] Univ Sao Paulo, Clin Immunol & Allergy Div, Sao Paulo, Brazil

[19] Respiralab, Guayaquil, Ecuador

[20] Fed Univ Sao Paulo Unifesp, Div Allergy & Clin Immunol, Sao Paulo, Brazil

[21] Univ Buenos Aires Buenos Aires, Fdn Libra, Fac Med, Buenos Aires, Argentina

[22] Hosp Univ Metropolitano Univ Metropolitana Barranq, Pediat Allergy Fdn, Clin Allergy, Barranquilla, Colombia

[23] Hosp Pedro Elizalde Buenos Aires, Buenos Aires, Argentina

[24] Faaaai Hosp San Angel Inn Chapultepec, Mexico City, Mexico

[25] 2496 2D,Caba, RA-1426 Buenos Aires, Argentina

来源：

WORLD ALLERGY ORGANIZATION JOURNAL | 2023年 / 16卷 / 02期

关键词：

Anaphylaxis; Latin America; Food hypersensitivity; Medication hypersensitivity; Insect venom hypersensitivity; DRUG-INDUCED ANAPHYLAXIS; TERTIARY-CARE; EMERGENCY-DEPARTMENT; CLINICAL-FEATURES; ALLERGY; SEVERITY; MANAGEMENT; EPIDEMIOLOGY; ADOLESCENTS; INCREASES;

D O I：

10.1016/j.waojou.2023.100748

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Recent data about clinical features, triggers and management of anaphylaxis in Latin America is lacking.Objective: To provide updated and extended data on anaphylaxis in this region.Method: An online questionnaire was used, with 67 allergy units involved from 12 Latin-American countries and Spain. Among data recorded, demographic information, clinical features, severity, triggering agents, and treatment were received.Results: Eight hundred and seventeen anaphylactic reactions were recorded. No difference in severity, regardless of pre-existing allergy or asthma history was found. Drug induced anaphylaxis (DIA) was most frequent (40.6%), followed by food induced anaphylaxis (FIA) (32.9%) and venom induced anaphylaxis (VIA) (12%). FIA and VIA were more common in children-adolescents. Non -steroidal anti-inflammatory drugs (NSAIDs) and beta-lactam antibiotics (BLA) were the most frequent drugs involved. Milk (61.1% of FIA) and egg (15.4% of FIA) in children, and shellfish (25.5% of FIA), fresh fruits (14.2% of FIA), and fish (11.3% of FIA) in adults were the most common FIA triggers. Fire ants were the most frequent insect triggers, and they induced more severe re-actions than triggers of FIA and DIA (p < 0.0001). Epinephrine was used in 43.8% of anaphylaxis episodes. After Emergency Department treatment, epinephrine was prescribed to 13% of patients.Conclusions: Drugs (NSAIDs and BLA), foods (milk and egg in children and shellfish, fruits and fish in adults) and fire ants were the most common inducers of anaphylaxis. Epinephrine was used in less than half of the episodes emphasizing the urgent need to improve dissemination and implementation of anaphylaxis guidelines.

引用

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