Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults

被引：4

作者：

Smevik, Hanne ^{[1
,2
]}

Habli, Sarah ^{[1
,2
]}

Saksvik, Simen Berg ^{[3
,4
]}

Kliem, Elisabeth ^{[1
]}

Evensmoen, Hallvard Roe ^{[5
,6
]}

Conde, Virginia ^{[1
,7
]}

Petroni, Agustin ^{[1
,8
]}

Asarnow, Robert F. ^{[9
,10
]}

Dennis, Emily L. ^{[11
]}

Eikenes, Live ^{[12
]}

Kallestad, Havard ^{[13
]}

Sand, Trond ^{[2
,14
]}

Thompson, Paul M. ^{[15
]}

Saksvik-Lehouillier, Ingvild ^{[1
]}

Haberg, Asta Kristine

Olsen, Alexander ^{[1
,2
,3
,16
]}

机构：

[1] Norwegian Univ Sci & Technol, Dept Psychol, Trondheim, Norway

[2] Norwegian Univ Sci & Technol, NorHEAD Norwegian Ctr Headache Res, Trondheim, Norway

[3] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Phys Med & Rehabil, Trondheim, Norway

[4] Norwegian Univ Sci & Technol, Dept Mental Hlth, Trondheim, Norway

[5] Norwegian Univ Sci & Technol, Dept Neuromed & Movement Sci, Trondheim, Norway

[6] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Radiol & Nucl Med, Trondheim, Norway

[7] Univ Oslo, Dept Psychol, Multimodal Imaging & Cognit Control Lab, Oslo, Norway

[8] Univ Buenos Aires, Lab Inteligencia Artificial Aplicada, Inst Ciencias Comp, CONICET, Buenos Aires, Argentina

[9] UCLA, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA

[10] UCLA, UCLA Sch Med, Dept Psychol, Los Angeles, CA USA

[11] Univ Utah, TBI & Concuss Ctr, Dept Neurol, Sch Med, Salt Lake City, UT USA

[12] Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, Trondheim, Norway

[13] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Mental Healthcare, Trondheim, Norway

[14] St Olavs Hosp, Dept Neurol & Clin Neurophysiol, Trondheim, Norway

[15] USC, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Keck Sch Med, Los Angeles, CA USA

[16] Norwegian Univ Sci & Technol, Dept Psychol, N-7491 Trondheim, Norway

来源：

CEREBRAL CORTEX | 2023年 / 33卷 / 11期

基金：

美国国家卫生研究院;

关键词：

continuous performance test; executive function; magnetic resonance imaging; neuropsychology; sleep; INSOMNIA SEVERITY INDEX; TIME-ON-TASK; HABITUAL SLEEP; DURATION; QUALITY; FMRI; PERFORMANCE; FATIGUE; MEMORY; ORGANIZATION;

D O I：

10.1093/cercor/bhad024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigated how proactive and reactive cognitive control processing in the brain was associated with habitual sleep health. BOLD fMRI data were acquired from 81 healthy adults with normal sleep (41 females, age 20.96-39.58 years) during a test of cognitive control (Not-X-CPT). Sleep health was assessed in the week before MRI scanning, using both objective (actigraphy) and self-report measures. Multiple measures indicating poorer sleep health-including later/more variable sleep timing, later chronotype preference, more insomnia symptoms, and lower sleep efficiency-were associated with stronger and more widespread BOLD activations in fronto-parietal and subcortical brain regions during cognitive control processing (adjusted for age, sex, education, and fMRI task performance). Most associations were found for reactive cognitive control activation, indicating that poorer sleep health is linked to a "hyper-reactive" brain state. Analysis of time-on-task effects showed that, with longer time on task, poorer sleep health was predominantly associated with increased proactive cognitive control activation, indicating recruitment of additional neural resources over time. Finally, shorter objective sleep duration was associated with lower BOLD activation with time on task and poorer task performance. In conclusion, even in "normal sleepers," relatively poorer sleep health is associated with altered cognitive control processing, possibly reflecting compensatory mechanisms and/or inefficient neural processing.

引用

页码：7100 / 7119

页数：20

共 190 条

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