Multifunctional Prosthesis Surface: Modification of Titanium with Cinnamaldehyde-Loaded Hierarchical Titanium Dioxide Nanotubes

被引:8
作者
Mao, Yi [1 ]
Xie, Xinru [1 ]
Sun, Guangxin [2 ]
Yu, Shiqi [3 ]
Ma, Mingqi [1 ]
Chao, Rui [1 ]
Wan, Tianhao [1 ]
Xu, Weifeng [1 ]
Chen, Xuzhuo [1 ]
Sun, Lei [1 ,4 ]
Zhang, Shanyong [1 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol, Natl Ctr Stomatol,Dept Oral Surg,Sch Med,Shanghai, Shanghai, Peoples R China
[2] China Med Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Shenyang 110002, Liaoning, Peoples R China
[3] Chongqing Med Univ, Dept Nursing, Affiliated Hosp 1, Chongqing 400016, Peoples R China
[4] Anhui Med Univ, Dept Stomatol, Affiliated Hosp 2, Hefei 230601, Anhui, Peoples R China
基金
中国博士后科学基金;
关键词
anti-inflammatory materials; antibacterials; bone osseointegration; osteoclastogenesis; titanium implants; TIO2; NANOTUBES; BONE; ANTIBACTERIAL; OSTEOGENESIS; ARTHROPLASTY; DERIVATIVES; FABRICATION; ROUGHNESS; IMPLANTS; ADHESION;
D O I
10.1002/adhm.202303374
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Orthopedic prostheses are the ultimate therapeutic solution for various end-stage orthopedic conditions. However, aseptic loosening and pyogenic infections remain as primary complications associated with these devices. In this study, a hierarchical titanium dioxide (TiO2) nanotube drug delivery system loaded with cinnamaldehyde for the surface modification of titanium implants, is constructed. These specially designed dual-layer TiO2 nanotubes enhance material reactivity and provide an extensive drug-loading platform within a short time. The introduction of cinnamaldehyde enhances the bone integration performance of the scaffold (simultaneously promoting bone formation and inhibiting bone resorption), anti-inflammatory capacity, and antibacterial properties. In vitro experiments have demonstrated that this system promoted osteogenesis by upregulating both Wnt/beta-catenin and MAPK signaling pathways. Furthermore, it inhibits osteoclast formation, suppresses macrophage-mediated inflammatory responses, and impedes the proliferation of Staphylococcus aureus and Escherichia coli. In vivo experiments shows that this material enhances bone integration in a rat model of femoral defects. In addition, it effectively enhances the antibacterial and anti-inflammatory properties in a subcutaneous implant in a rat model. This study provides a straightforward and highly effective surface modification strategy for orthopedic Ti implants. A dual-layered nanotube structure of titanium dioxide (TiO2) loaded with cinnamaldehyde promotes bone integration, anti-inflammation, and antibacterial properties in surface modification of titanium metal. image
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页数:20
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