Multifunctional Prosthesis Surface: Modification of Titanium with Cinnamaldehyde-Loaded Hierarchical Titanium Dioxide Nanotubes

被引:8
作者
Mao, Yi [1 ]
Xie, Xinru [1 ]
Sun, Guangxin [2 ]
Yu, Shiqi [3 ]
Ma, Mingqi [1 ]
Chao, Rui [1 ]
Wan, Tianhao [1 ]
Xu, Weifeng [1 ]
Chen, Xuzhuo [1 ]
Sun, Lei [1 ,4 ]
Zhang, Shanyong [1 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol, Natl Ctr Stomatol,Dept Oral Surg,Sch Med,Shanghai, Shanghai, Peoples R China
[2] China Med Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Shenyang 110002, Liaoning, Peoples R China
[3] Chongqing Med Univ, Dept Nursing, Affiliated Hosp 1, Chongqing 400016, Peoples R China
[4] Anhui Med Univ, Dept Stomatol, Affiliated Hosp 2, Hefei 230601, Anhui, Peoples R China
基金
中国博士后科学基金;
关键词
anti-inflammatory materials; antibacterials; bone osseointegration; osteoclastogenesis; titanium implants; TIO2; NANOTUBES; BONE; ANTIBACTERIAL; OSTEOGENESIS; ARTHROPLASTY; DERIVATIVES; FABRICATION; ROUGHNESS; IMPLANTS; ADHESION;
D O I
10.1002/adhm.202303374
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Orthopedic prostheses are the ultimate therapeutic solution for various end-stage orthopedic conditions. However, aseptic loosening and pyogenic infections remain as primary complications associated with these devices. In this study, a hierarchical titanium dioxide (TiO2) nanotube drug delivery system loaded with cinnamaldehyde for the surface modification of titanium implants, is constructed. These specially designed dual-layer TiO2 nanotubes enhance material reactivity and provide an extensive drug-loading platform within a short time. The introduction of cinnamaldehyde enhances the bone integration performance of the scaffold (simultaneously promoting bone formation and inhibiting bone resorption), anti-inflammatory capacity, and antibacterial properties. In vitro experiments have demonstrated that this system promoted osteogenesis by upregulating both Wnt/beta-catenin and MAPK signaling pathways. Furthermore, it inhibits osteoclast formation, suppresses macrophage-mediated inflammatory responses, and impedes the proliferation of Staphylococcus aureus and Escherichia coli. In vivo experiments shows that this material enhances bone integration in a rat model of femoral defects. In addition, it effectively enhances the antibacterial and anti-inflammatory properties in a subcutaneous implant in a rat model. This study provides a straightforward and highly effective surface modification strategy for orthopedic Ti implants. A dual-layered nanotube structure of titanium dioxide (TiO2) loaded with cinnamaldehyde promotes bone integration, anti-inflammation, and antibacterial properties in surface modification of titanium metal. image
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页数:20
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共 88 条
[1]   Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells [J].
Ahn, Sejin ;
Kim, Eunhee ;
Lee, Kooyeon ;
Lee, Deug-Chan .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2016, 38 :342-348
[2]  
Arkudas A, 2018, TISSUE ENG PT A, V24, P479, DOI [10.1089/ten.TEA.2017.0110, 10.1089/ten.tea.2017.0110]
[3]   Vinculin in cell-cell and cell-matrix adhesions [J].
Bays, Jennifer L. ;
DeMali, Kris A. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2017, 74 (16) :2999-3009
[4]  
Boyan BD, 2017, TISSUE ENG PT A, V23, P1479, DOI [10.1089/ten.tea.2017.0048, 10.1089/ten.TEA.2017.0048]
[5]   TiO2 nanotubes for bone regeneration [J].
Brammer, Karla S. ;
Frandsen, Christine J. ;
Jin, Sungho .
TRENDS IN BIOTECHNOLOGY, 2012, 30 (06) :315-322
[6]   Reverse total shoulder arthroplasty A SYSTEMATIC REVIEW AND META-ANALYSIS OF COMPLICATIONS AND PATIENT OUTCOMES DEPENDENT ON PROSTHESIS DESIGN [J].
Burden, E. G. ;
Batten, T. J. ;
Smith, C. D. ;
Evans, J. P. .
BONE & JOINT JOURNAL, 2021, 103B (05) :813-821
[7]   Revision Reverse Shoulder Arthroplasty [J].
Chalmers, Peter N. ;
Boileau, Pascal ;
Romeo, Anthony A. ;
Tashjian, Robert Z. .
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 2019, 27 (12) :426-436
[8]   Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling [J].
Chao, Louis Kuoping ;
Hua, Kuo-Feng ;
Hsu, Hsien-Yeh ;
Cheng, Sen-Sung ;
Lin, I-Fan ;
Chen, Chia-Jung ;
Chen, Shui-Tein ;
Chang, Shang-Tzen .
FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (01) :220-231
[9]   Nanocatalytic Biofunctional MOF Coating on Titanium Implants Promotes Osteoporotic Bone Regeneration through Cooperative Proosteoblastogenesis MSC Reprogramming [J].
Chen, Maowen ;
Wang, Dong ;
Li, Menghuan ;
He, Ye ;
He, Tingting ;
Chen, Maohua ;
Hu, Yan ;
Luo, Zhong ;
Cai, Kaiyong .
ACS NANO, 2022, 16 (09) :15397-15412
[10]   LY411575, a potent γ-secretase inhibitor, suppresses osteoclastogenesis in vitro and LPS-induced calvarial osteolysis in vivo [J].
Chen, Xinwei ;
Chen, Xuzhuo ;
Zhou, Zhihang ;
Qin, An ;
Wang, Yexin ;
Fan, Baoting ;
Xu, Weifeng ;
Zhang, Shanyong .
JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (11) :20944-20956