Interplay Between TGF-β Signaling and MicroRNA in Diabetic Cardiomyopathy

被引：2
作者：
Qin, Jianning [1 ]
Tan, Yao [1 ]
Han, Yang [1 ]
Yu, Letian [1 ]
Liu, Shali [1 ]
Zhao, Simin [1 ]
Wan, Hengquan [1 ]
Qu, Shunlin [1 ]
机构：
[1] Univ South China, Key Lab Arteriosclerol Hunan Prov, Hunan Int Sci & Technol Cooperat Base Arterioscle, Pathophysiol Dept,Inst Cardiovasc Dis, Hongxiang St, Hengyang 421001, Hunan, Peoples R China
来源：
CARDIOVASCULAR DRUGS AND THERAPY | 2023年 / 39卷 / 3期
关键词：
MicroRNA; Diabetic cardiomyopathy; TGF-beta signaling pathway; LEFT-VENTRICULAR HYPERTROPHY; TO-MESENCHYMAL TRANSITION; CARDIAC FIBROSIS; INSULIN-RESISTANCE; SMAD PROTEINS; C-SKI; APOPTOSIS; RECEPTOR; TGF-BETA-1; COLLAGEN;
D O I：
10.1007/s10557-023-07532-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In diabetic patients, concomitant cardiovascular disease is the main factor contributing to their morbidity and mortality. Diabetic cardiomyopathy (DCM) is a form of cardiovascular disease associated with diabetes that can result in heart failure. Transforming growth factor-beta (TGF-beta) isoforms play a crucial role in heart remodeling and repair and are elevated and activated in myocardial disorders. Alterations in certain microRNAs (miRNA) are closely related to diabetic cardiomyopathy. One or more miRNA molecules target the majority of TGF-beta pathway components, and TGF-beta directly or via SMADs controls miRNA synthesis. Based on these interactions, this review discusses potential cross-talk between TGF-beta signaling and miRNA in DCM in order to investigate the creation of potential therapeutic targets.
引用
收藏
页码：633 / 641
页数：9
相关论文
共 81 条
  • [1] Ahmed U, 2021, CRIT REV EUKAR GENE, V31, P79, DOI 10.1615/CritRevEukaryotGeneExpr.2021037533
  • [2] Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways
    Anderson, Ethan J.
    Rodriguez, Evelio
    Anderson, Curtis A.
    Thayne, Kathleen
    Chitwood, W. Randolph
    Kypson, Alan P.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2011, 300 (01): : H118 - H124
  • [3] The Pathophysiological Basis of Diabetic Cardiomyopathy Development
    Avagimyan, Ashot
    Popov, Sergey
    Shalnova, Svetlana
    [J]. CURRENT PROBLEMS IN CARDIOLOGY, 2022, 47 (09)
  • [4] Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice
    Biernacka, Anna
    Cavalera, Michele
    Wang, Junhong
    Russo, Ilaria
    Shinde, Arti
    Kong, Ping
    Gonzalez-Quesada, Carlos
    Rai, Vikrant
    Dobaczewski, Marcin
    Lee, Dong-Wook
    Wang, Xiao-Fan
    Frangogiannis, Nikolaos G.
    [J]. CIRCULATION-HEART FAILURE, 2015, 8 (04) : 788 - U191
  • [5] High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy
    Bugyei-Twum, Antoinette
    Advani, Andrew
    Advani, Suzanne L.
    Zhang, Yuan
    Thai, Kerri
    Kelly, Darren J.
    Connelly, Kim A.
    [J]. CARDIOVASCULAR DIABETOLOGY, 2014, 13
  • [6] Crosstalk between TGF-β signaling and the microRNA machinery
    Butz, Henriett
    Racz, Karoly
    Hunyady, Laszlo
    Patocs, Attila
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2012, 33 (07) : 382 - 393
  • [7] Genetic analysis of the mammalian transforming growth factor-β superfamily
    Chang, H
    Brown, CW
    Matzuk, MM
    [J]. ENDOCRINE REVIEWS, 2002, 23 (06) : 787 - 823
  • [8] Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy
    Che, Hui
    Wang, Yueqiu
    Li, Hui
    Li, Yang
    Sahil, Abbas
    Lv, Jie
    Liu, Yining
    Yang, Zhenyu
    Dong, Ruixue
    Xue, Hongru
    Wang, Lihong
    [J]. FASEB JOURNAL, 2020, 34 (04) : 5282 - 5298
  • [9] Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts
    Che, Hui
    Wang, Yueqiu
    Li, Yang
    Lv, Jie
    Li, Hui
    Liu, Yining
    Dong, Ruixue
    Sun, Yongle
    Xu, Xiaodan
    Zhao, Jie
    Wang, Lihong
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 235 (11) : 7769 - 7779
  • [10] Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes
    Chen, Shali
    Puthanveetil, Prasanth
    Feng, Biao
    Matkovich, Scot J.
    Dorn, Gerald W., II
    Chakrabarti, Subrata
    [J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2014, 18 (03) : 415 - 421
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