Endothelium dysfunction and thrombosis in COVID-19 with type 2 diabetes

被引:6
作者
Li, Mengdi [1 ,2 ]
Wu, Xiaoming [2 ]
Shi, Jialan [2 ,3 ,4 ]
Niu, Yumei [1 ]
机构
[1] Harbin Med Univ, Hosp 1, Dept Endodont, Harbin, Peoples R China
[2] Harbin Med Univ, Hosp 1, Dept Hematol, Harbin, Peoples R China
[3] Harvard Med Sch, Dept Res, VA Boston Healthcare Syst, Boston, MA USA
[4] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA
基金
中国国家自然科学基金;
关键词
COVID-19; Diabetes; Type; 2; Endothelial cells; Phosphatidylserine; Thrombosis; INSULIN-RESISTANCE; CELL INFECTION; PHOSPHATIDYLSERINE; METFORMIN; DISEASE; THROMBOPROPHYLAXIS; ANTICOAGULATION; METABOLISM; THROMBOEMBOLISM; PROPHYLAXIS;
D O I
10.1007/s12020-023-03439-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
SARS-CoV-2 can directly or indirectly damage endothelial cells. Endothelial injury, especially phosphatidylserine (PS) exposure on the outer membrane of cells, can more easily promote thrombosis. Type 2 diabetes(T2D) patients were more susceptible to COVID-19, they had more severe symptoms, higher risk of thrombotic complications, and longer duration of post-COVID-19 sequelae. This review provided a detailed overview of the mechanisms underlying endothelial dysfunction in T2D patients with COVID-19 (including long COVID), which may be influenced by hyperglycemia, hypoxia, and pro-inflammatory environments. The mechanisms of thrombosis in T2D patients with COVID-19 are also explored, particularly the effects of increased numbers of PS-exposing particles, blood cells, and endothelial cells on hypercoagulability. Given the high risk of thrombosis in T2D patients with COVID-19, early antithrombotic therapy can both minimize the impact of the disease on patients and maximize the chances of improvement, thereby alleviating patient suffering. We provided detailed guidance on antithrombotic drugs and dosages for mild, moderate, and severe patients, emphasizing that the optimal timing of thromboprophylaxis is a critical factor in influencing prognosis. Considering the potential interactions between antidiabetic, anticoagulant, and antiviral drugs, we proposed practical and comprehensive management recommendations to supplement the incomplete efficacy of vaccines in the diabetic population, reduce the incidence of post-COVID-19 sequelae, and improve patient quality of life.
引用
收藏
页码:15 / 27
页数:13
相关论文
共 141 条
[1]   L-Arginine and COVID-19: An Update [J].
Adebayo, Ayobami ;
Varzideh, Fahimeh ;
Wilson, Scott ;
Gambardella, Jessica ;
Eacobacci, Michael ;
Jankauskas, Stanislovas S. ;
Donkor, Kwame ;
Kansakar, Urna ;
Trimarco, Valentina ;
Mone, Pasquale ;
Lombardi, Angela ;
Santulli, Gaetano .
NUTRIENTS, 2021, 13 (11)
[2]   COVID-19 and thrombosis: From bench to bedside [J].
Ali, Mohammad A. M. ;
Spinler, Sarah A. .
TRENDS IN CARDIOVASCULAR MEDICINE, 2021, 31 (03) :143-160
[3]   Nitrogenase Inhibition Limited Oxygenation of Earth's Proterozoic Atmosphere [J].
Allen, John F. ;
Thake, Brenda ;
Martin, William F. .
TRENDS IN PLANT SCIENCE, 2019, 24 (11) :1022-1031
[4]   COVID-19 vaccination: The road ahead [J].
Altmann, Daniel M. ;
Boyton, Rosemary J. .
SCIENCE, 2022, 375 (6585) :1127-1132
[5]   COVID-19, Renin-Angiotensin System and Endothelial Dysfunction [J].
Amraei, Razie ;
Rahimi, Nader .
CELLS, 2020, 9 (07)
[6]   Impact of Chronic Kidney Disease on Platelet Function Profiles in Diabetes Mellitus Patients With Coronary Artery Disease Taking Dual Antiplatelet Therapy [J].
Angiolillo, Dominick J. ;
Bernardo, Esther ;
Capodanno, Davide ;
Vivas, David ;
Sabate, Manel ;
Ferreiro, Jose Luis ;
Ueno, Masafumi ;
Jimenez-Quevedo, Pilar ;
Alfonso, Fernando ;
Bass, Theodore A. ;
Macaya, Carlos ;
Fernandez-Ortiz, Antonio .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (11) :1139-1146
[7]   COVID-19 in people with diabetes: understanding the reasons for worse outcomes [J].
Apicella, Matteo ;
Campopiano, Maria Cristina ;
Mantuano, Michele ;
Mazoni, Laura ;
Coppelli, Alberto ;
Prato, Stefano Del .
LANCET DIABETES & ENDOCRINOLOGY, 2020, 8 (09) :782-792
[8]   Comparing alternative approaches to measuring the geographical accessibility of urban health services: Distance types and aggregation-error issues [J].
Apparicio, Philippe ;
Abdelmajid, Mohamed ;
Riva, Mylene ;
Shearmur, Richard .
INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS, 2008, 7 (1)
[9]   Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study [J].
Ayoubkhani, Daniel ;
Khunti, Kamlesh ;
Nafilyan, Vahe ;
Maddox, Thomas ;
Humberstone, Ben ;
Diamond, Ian ;
Banerjee, Amitava .
BMJ-BRITISH MEDICAL JOURNAL, 2021, 372
[10]   Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19 A Randomized Clinical Trial [J].
Berger, Jeffrey S. ;
Kornblith, Lucy Z. ;
Gong, Michelle N. ;
Reynolds, Harmony R. ;
Cushman, Mary ;
Cheng, Yu ;
McVerry, Bryan J. ;
Kim, Keri S. ;
Lopes, Renato D. ;
Atassi, Bassel ;
Berry, Scott ;
Bochicchio, Grant ;
Antunes, Murillo de Oliveira ;
Farkouh, Michael E. ;
Greenstein, Yonatan ;
Hade, Erinn M. ;
Hudock, Kristin ;
Hyzy, Robert ;
Khatri, Pooja ;
Kindzelski, Andrei ;
Kirwan, Bridget-Anne ;
Kreuziger, Lisa Baumann ;
Lawler, Patrick R. ;
Leifer, Eric ;
Moreno, Jose Lopez-Sendon ;
Lopez-Sendon, Jose ;
Luther, James F. ;
Maia, Lilia Nigro ;
Quigley, John ;
Sherwin, Robert ;
Wahid, Lana ;
Wilson, Jennifer ;
Hochman, Judith S. ;
Neal, Matthew D. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327 (03) :227-236