Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives

被引:94
作者
Xu, Hongwei [1 ]
Zhang, Ying [2 ]
Zhang, Haotian [3 ]
Zhang, Yunran [4 ]
Xu, Qingqing [1 ]
Lu, Junya [1 ]
Feng, Shuaipeng [1 ]
Luo, Xinyi [1 ]
Wang, Siling [1 ]
Zhao, Qinfu [1 ]
机构
[1] Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
[3] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang, Peoples R China
[4] Changzhou Pharmaceut Factory Co LTD, 518 East Laodong Rd, Changzhou, Jiangsu, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Polydopamine-derived nanoplatforms; Multifunctional groups; Photothermal therapy -assisted tumor therapy; Tumor theranostics; Antibacterials; Antioxidant; MESOPOROUS SILICA NANOPARTICLES; COMBINED PHOTOTHERMAL THERAPY; MELANIN-LIKE NANOPARTICLES; THERANOSTIC AGENT; MULTIDRUG-RESISTANCE; AUTOPHAGY INHIBITION; HOLLOW POLYDOPAMINE; CELLULAR UPTAKE; CANCER; SHELL;
D O I
10.1016/j.ccr.2023.215153
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Thanks to rapid development of nanotechnology, studies have discovered an emerging polymer nano-material-polydopamine (PDA) inspired by natural mussels. PDA possesses many outstanding characteristics, including broad light absorption, high reactivity, simple preparation and free radical scavenging. Therefore, the diverse PDA-derived nanoplatforms have been developed for multiple applications, including tumor treatment, imaging, antibacterials and antioxidant. This review aims to outline the advancements of PDA-derived nano -materials in photothermal therapy (PTT)-assisted tumor therapy, theranostics, antibacterials, antioxidant and delivery of active molecules, including preparation methods, potential polymerization mechanism and various nanostructures of PDA as well. The existing limitations of PDA-derived nanoparticles are also rationally discussed.
引用
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页数:24
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