Design and synthesis of ether derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment

被引：3

作者：

Hirabayashi, Satoru ^{[1
]}

Li, Yue ^{[2
]}

Ohta, Noriko ^{[2
]}

Ishibashi, Airi ^{[2
]}

Yoshikawa, Yusuke ^{[1
]}

Lin, Bangzhong ^{[1
]}

Fumimoto, Megumi ^{[1
]}

Takehara, Tsunayoshi ^{[3
]}

Nunomura, Kazuto ^{[1
]}

Suzuki, Takeyuki ^{[3
]}

Haruta, Junichi ^{[1
]}

Nimura, Keisuke ^{[2
]}

Arisawa, Mitsuhiro ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Yamada Oka 1-6, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Dept Genome Biol, Div Gene Therapy Sci, 2-2 Yamada Oka, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Comprehens Anal Ctr, Sanken, Mihogaoka 8-1, Osaka, Ibaraki 5670047, Japan

来源：

TETRAHEDRON LETTERS | 2023年 / 114卷

关键词：

Prostate cancer; splicing variant; spliceostatin A; Hydrogen bond; ENZALUTAMIDE;

D O I：

10.1016/j.tetlet.2022.154288

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

To confirm the hypothesis that the terminal epoxide structure of spliceostatin A may be active through hydrogen bond formation, we designed and synthesized novel ether derivatives of spliceostatin A, whose terminal epoxide is replaced with an ether-based moiety capable of hydrogen bond formation. The results of biological evaluation against AR-V7 and the conformational analysis of each derivative suggest that the terminal epoxide moiety of spliceostatin A expresses its activity through covalent bond forma-tion rather than hydrogen bond formation.(c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：5

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