Heart Failure with Preserved Ejection Fraction: a Pharmacotherapeutic Update

被引：6

作者：

Vaz-Salvador, Pedro ^{[1
]}

Adao, Rui ^{[1
]}

Vasconcelos, Ines ^{[1
]}

Leite-Moreira, Adelino F. ^{[1
]}

Bras-Silva, Carmen ^{[1
,2
]}

机构：

[1] Univ Porto, Fac Med, Cardiovasc Res & Dev Ctr UnIC, Dept Surg & Physiol, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal

[2] Univ Porto, Fac Nutr & Food Sci, Rua Campo Alegre, P-823415018 Porto, Portugal

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 2023年 / 37卷 / 04期

关键词：

Heart failure; Preserved ejection fraction; Pharmacotherapy; Clinical trials; QUALITY-OF-LIFE; CONVERTING ENZYME-INHIBITION; SOLUBLE GUANYLATE-CYCLASE; CORONARY-ARTERY-DISEASE; EXERCISE CAPACITY; DOUBLE-BLIND; DIASTOLIC DYSFUNCTION; IRON-DEFICIENCY; ECONOMIC BURDEN; CLINICAL STATUS;

D O I：

10.1007/s10557-021-07306-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

While guidelines for management of heart failure with reduced ejection fraction (HFrEF) are consensual and have led to improved survival, treatment options for heart failure with preserved ejection fraction (HFpEF) remain limited and aim primarily for symptom relief and improvement of quality of life. Due to the shortage of therapeutic options, several drugs have been investigated in multiple clinical trials. The majority of these trials have reported disappointing results and have suggested that HFpEF might not be as simply described by ejection fraction as previously though. In fact, HFpEF is a complex clinical syndrome with various comorbidities and overlapping distinct phenotypes that could benefit from personalized therapeutic approaches. This review summarizes the results from the most recent phase III clinical trials for HFpEF and the most promising drugs arising from phase II trials as well as the various challenges that are currently holding back the development of new pharmacotherapeutic options for these patients.

引用

页码：815 / 832

页数：18

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