A 5+1-Axis 3D Printing Platform for Producing Customized Intestinal Fistula Stents

被引：4

作者：

Hu, Qingxi ^{[1
,2
,3
]}

Cui, Jian ^{[1
]}

Zhang, Haiguang ^{[1
,2
,3
]}

Liu, Suihong ^{[1
]}

Ramalingam, Murugan ^{[4
]}

机构：

[1] Shanghai Univ, Rapid Mfg Engn Ctr, Sch Mechatron Engn & Automat, Shanghai 200444, Peoples R China

[2] Shanghai Univ, Shanghai Key Lab Intelligent Mfg & Robot, Shanghai, Peoples R China

[3] Shanghai Univ, Natl Demonstrat Ctr Expt Engn Training Educ, Shanghai, Peoples R China

[4] Vellore Inst Technol, Sch Mech Engn, Ctr Biomat Cellular & Mol Theranost, Biomat & Organ Engn Grp, Vellore, Tamil Nadu, India

来源：

3D PRINTING AND ADDITIVE MANUFACTURING | 2023年 / 10卷 / 05期

基金：

中国国家自然科学基金;

关键词：

bio-printing; enteroatmospheric fistula; 5-axis; linkage; open abdomen; Thermoplastic polyurethane; ENTEROATMOSPHERIC FISTULA; MANAGEMENT;

D O I：

10.1089/3dp.2021.0044

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Tailored intestinal fistula stents with a hollow bent pipe structure prepared by using a three-axis bio-printing platform are often unsuitable due to low printing efficiency and quality caused by the unavoidable need for a supporting structure. Herein, a 5 + 1-axis 3D printing platform was built and developed for producing support-free intestinal fistula stents. A 3D model of the target stent shape and dimensions was treated by a dynamic slicing algorithm, which was then used to prepare a motion control code. Our printing method showed improved printing efficiency, superior stent surface properties and structure and ideal elasticity and mechanical strength to meet the mechanical requirements of the human body. Static simulations showed the importance of axial printing techniques, whereas the stent itself was shown to have excellent biocompatibility with wettability and cell proliferation tests. We present a customizable, efficient, and high-quality method with the potential for preparing bespoke stents for treating intestinal fistulas.

引用

页码：955 / 970

页数：16

共 33 条

[31] Construction and Biocompatibility of Three-Dimensional Composite Polyurethane Scaffolds in Liquid Crystal State [J].