Role of O-GlcNAcylation in cancer biology

被引：3
作者：
Li, Yuxuan [1 ,2 ]
Qu, Shuhan [1 ,2 ]
Jin, Hai [3 ]
Jia, Qingge [4 ]
Li, Mingyang [1 ,2 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Pathol, State Key Lab Canc Biol, Xian, Peoples R China
[2] Fourth Mil Med Univ, Sch Basic Med, Xian, Peoples R China
[3] Gen Hosp Northern Theater Command, Dept Neurosurg, Shenyang, Peoples R China
[4] Northwest Univ, Xian Int Med Ctr Hosp, Dept Reprod Med, Xian, Peoples R China
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 253卷
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
O-GlcNAcylation; Cancer; Tumor phenotypes; NF-KAPPA-B; GLCNAC-MODIFICATION; ONCOGENIC TRANSCRIPTION; PANCREATIC-CANCER; CROSS-TALK; GLUCOSE; PHOSPHORYLATION; CELLS; ACETYLGLUCOSAMINE; INFLAMMATION;
D O I：
10.1016/j.prp.2023.155001
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
One of the general characteristics of cancer cells is the abnormal increase of O-GlcNAcylation. Recent studies have shown that it affects the basic functions of proteins and regulates multiple phenotypes of cancer cells through key signals and metabolic pathways. O-GlcNAcylation is a covalent linkage between the beta-D-N-acetyl-glucosamine (GlcNAc) sugar and target protein. It interacts with many other types of post-translational modifications and works together in the whole process of cancer development. For example, it regulates cell activities such as cell signal transduction, transcription, cell division, metabolism and cytoskeleton regulation. In this review, we summarized the general concept of O-GlcNAcylation and its related role in the ten major tumor phenotypes.
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页数：10
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