Synthesis and Some Properties of New Bromo Derivatives of Isobornylphenols

被引：0
|
作者：
Kolegova, T. A. [1 ]
Chukicheva, I. Yu. [1 ]
Shevchenko, O. G. [2 ]
Kutchin, A. V. [1 ]
机构：
[1] Russian Acad Sci, Inst Chem, Komi Sci Ctr, Ural Branch, Syktyvkar 167000, Russia
[2] Russian Acad Sci, Inst Biol, Ural Branch, Komi Sci Ctr, Syktyvkar 167982, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 08期
关键词：
isobornylphenols; N-bromosuccinimide; bromination; bromine-containing derivatives; antioxidant activity; oxidative hemolysis; AROMATIC-COMPOUNDS; NUCLEAR BROMINATION; EFFICIENT; ANTIOXIDANT; NBS; MONOBROMINATION; ALKYLATION; ANILINES; CATALYST;
D O I：
10.1134/S1070363223080054
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We determined optimal conditions to brominate various isobornyl phenols with molecular bromine and N-bromosuccinimide as well as studied oxidative bromination of them with KBr-Oxone (R). For obtained brominated derivatives, as isobornylphenols, an assessment of erythrotoxicity, membrane-protective and antioxidant activity was performed using in vitro models. Halogen derivatives of isobornylphenols containing a bromine atom in the para-position and an alkyl fragment in the ortho-position relative to the phenolic hydroxyl group showed high antioxidant activity in the model of oxidative hemolysis of erythrocytes.
引用
收藏
页码：1966 / 1979
页数：14
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