[3+2] cycloaddition for the assembly of indolizine-based heterocyclic sulfonyl fluorides

被引：13

作者：

Xiong, Huan ^{[1
,2
]}

Wu, Jianping ^{[1
,2
]}

Qin, Hua-Li ^{[1
,2
]}

机构：

[1] Wuhan Univ Technol, Chem Engn & Life Sci, Sch Chem, Wuhan 430070, Peoples R China

[2] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 02期

基金：

中国国家自然科学基金;

关键词：

BIOLOGICAL-ACTIVITY; SUFEX CLICK; INHIBITORS;

D O I：

10.1039/d2qo01466a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Presented herein is a method for the construction of indolizine-based heterocyclic sulfonyl fluorides through [3 + 2] cycloaddition of isoquinolinium/quinolinium salts and 1-bromoethene-1-sulfonyl fluoride (BESF), driven by Et3N and 4,5-dichloro-3,6-dioxocyclohexa-1,4-diene-1,2-dicarbonitrile (DDQ). This transformation features mild conditions, high efficiency, easily obtained starting materials, and broad substrate scope, providing a great potential value in medicinal chemistry and other related disciplines.

引用

页码：342 / 347

页数：6

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