Hepatic metabolism-related effects of polysaccharides from red kidney bean and small black soybean on type 2 diabetes

被引：31

作者：

Bai, Zhouya ^{[1
,2
]}

Huang, Xiaojun ^{[1
]}

Wu, Guangjie ^{[1
,3
]}

Zhou, Yujia ^{[1
]}

Deng, Xingchao ^{[1
]}

Yang, Jingrui ^{[1
]}

Yin, Junyi ^{[1
]}

Nie, Shaoping ^{[1
]}

机构：

[1] Nanchang Univ, State Key Lab Food Sci & Technol, China Canada Joint Lab Food Sci & Technol Nanchang, 235 Nanjing East Rd, Nanchang 330047, Peoples R China

[2] Henan Univ Sci & Technol, Coll Food & Bioengn, Luoyang 471023, Henan, Peoples R China

[3] Jiangxi Sci & Technol Normal Univ, Sch Life Sci, 605 Fenglin St, Nanchang 330013, Jiangxi, Peoples R China

来源：

FOOD CHEMISTRY | 2023年 / 403卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Red kidney bean polysaccharides; Small black soybean; Polysaccharides; Hepatic metabolism; Type; 2; diabetes; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; LIVER; MICROBIOTA; MELLITUS; GLUCOSE; INSULIN; DISEASE; HEALTH; RATIO;

D O I：

10.1016/j.foodchem.2022.134334

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In our previous study, two crude polysaccharides from red kidney bean and small black soybean (RK, SB) have shown the alleviative effect on type 2 diabetic mice. Meanwhile, hepatic dysfunction usually accompanied with type 2 diabetes mellitus (T2DM), and closely related to glucose and lipid homeostasis. Therefore, this time we further investigated the protective effect on hepatic dysfunction of RK and SB. Results found that both crude polysaccharides had the protective effects. In addition, investigation on purified polysaccharides identified that the polysaccharide was the biofunctional component basis in crude RK and SB. Subsequently, further research investigated the regulating mechanism of two pure polysaccharides (RKPH and SBPH) on hepatic metabolism and lipid metabolism. The results showed the improved different metabolites of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by RKPH and SBPH to affect glycerophospholipid metabolism pathway might be involved in the improvement of the glucose, lipids homeostasis and liver function in T2DM.

引用

页数：9

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