What is the effectiveness of surgical and non-surgical therapies in the treatment of ischemic priapism in patients with sickle cell disease? A systematic review by the EAU Sexual and Reproductive Health Guidelines Panel

被引：4

作者：

Gul, M. ^{[1
]}

Luca, B. ^{[2
]}

Dimitropoulos, K. ^{[3
]}

Capogrosso, P. ^{[4
,5
]}

Milenkovic, U. ^{[6
]}

Cocci, A. ^{[7
]}

Veeratterapillay, R. ^{[8
]}

Hatzichristodoulou, G. ^{[9
]}

Modgil, V ^{[10
]}

Russo, G., I ^{[11
]}

Tharakan, T. ^{[12
]}

Kalkanli, A. ^{[13
]}

Omar, M., I ^{[3
]}

Bettocchi, C. ^{[14
]}

Carvalho, J. ^{[15
]}

Corona, G. ^{[16
]}

Jones, T. H. ^{[17
]}

Kadioglu, A. ^{[18
]}

Martinez-Salamanca, J., I ^{[19
]}

Serefoglu, E. C. ^{[20
]}

Verze, P. ^{[21
]}

Minhas, S. ^{[22
]}

Salonia, A. ^{[23
,24
]}

机构：

[1] Selcuk Univ, Sch Med, Urol, Dept Urol, Konya, Turkiye

[2] IRCCS Osped San Raffaele, Urol Res Inst, Expt Oncol, Unit Urol, Milan, Italy

[3] Univ Aberdeen, Acad Urol Unit, Aberdeen, Scotland

[4] Univ Insurbria, ASST Sette Laghi, Circolo, Varese, Italy

[5] Univ Insurbria, Fdn Macchi Hosp, Varese, Italy

[6] Univ Leuven, Lab Expt Urol, Leuven, Belgium

[7] Univ Florence, Careggi Hosp, Urol, Florence, Italy

[8] Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Urol, Newcastle Upon Tyne, Tyne & Wear, England

[9] Julius Maximilians Univ Wurzburg, Urol & Pediat Urol, Wurzburg, Germany

[10] Manchester Univ Hosp NHS Fdn Trust, Manchester Royal Infirm, Manchester Androl Ctr, Manchester, Lancs, England

[11] Univ Catania, Urol, Catania, Italy

[12] Imperial Coll Healthcare NHS Trust, Charing Cross Hosp, Urol, London, England

[13] Taksim Educ & Res Hosp, Dept Urol, Istanbul, Turkiye

[14] Univ Foggia, Dept Urol, Foggia, Italy

[15] Lusofona Univ Humanities & Technol, Sch Psychol & Life Sci, Lisbon, Portugal

[16] Azienda Usl Bologna Maggiore, Bellaria Hosp, Endocrinol Unit, Bologna, Italy

[17] Univ Sheffield Med Sch, Oncol & Metab, Sheffield, S Yorkshire, England

[18] Istanbul Univ, Urol, Istanbul, Turkiye

[19] Hosp Univ Puerta de Hierro Majadahonda, Madrid, Spain

[20] Biruni Univ, Urol, Istanbul, Turkiye

[21] Univ Naples Federico II, Urol, Naples, Italy

[22] Imperial Healthcare NHS Trust, Urol, Charing Cross Hosp, London, England

[23] URI Urol Res Inst, Expt Oncol, Unit Urol, Milan, Italy

[24] Univ Vita Salute San Raffaele, Milan, Italy

来源：

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2024年 / 36卷 / 01期

关键词：

STUTTERING PRIAPISM; EXCHANGE-TRANSFUSION; NADPH OXIDASE; MANAGEMENT; ANEMIA; SILDENAFIL; PREVENTION; INJECTION; CHILDREN; PATHOPHYSIOLOGY;

D O I：

10.1038/s41443-022-00590-4

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Sickle cell disease (SCD) is an inherited hemoglobin disorder characterized by the occlusion of small blood vessels by sickle-shaped red blood cells. SCD is associated with a number of complications, including ischemic priapism. While SCD accounts for at least one-third of all priapism cases, no definitive treatment strategy has been established to specifically treat patients with SC priapism. The aim of this systematic review was to assess the efficacy and safety of contemporary treatment modalities for acute and stuttering ischemic priapism associated with SCD. The primary outcome measures were defined as resolution of acute priapism (detumescence) and complete response of stuttering priapism, while the primary harm outcome was as sexual dysfunction. The protocol for the review has been registered (PROSPERO Nr: CRD42020182001), and a systematic search of Medline, Embase, and Cochrane controlled trials databases was performed. Three trials with 41 observational studies met the criteria for inclusion in this review. None of the trials assessed detumescence, as a primary outcome. All of the trials reported a complete response of stuttering priapism; however, the certainty of the evidence was low. It is clear that assessing the effectiveness of specific interventions for priapism in SCD, well-designed, adequately-powered, multicenter trials are strongly required.

引用

页码：20 / 35

页数：16

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