Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling

被引：7

作者：

Laudadio, Gabriele ^{[1
]}

Neigenfind, Philipp ^{[1
]}

Chebolu, Rajesh ^{[2
]}

Blasczak, Vanna D. ^{[3
]}

Maddirala, Shambabu Joseph ^{[2
]}

Palkowitz, Maximilian D. ^{[1
]}

Bolduc, Philippe N. ^{[3
]}

Nicastri, Michael C. ^{[3
]}

Puthukanoori, Ravi Kumar ^{[2
]}

Paraselli, Bheema Rao ^{[2
,4
]}

Baran, Phil S. ^{[1
]}

机构：

[1] Scripps Res, Dept Chem, La Jolla, CA 92037 USA

[2] Chemveda Life Sci Pvt Ltd, Hyderabad 500039, Telangana, India

[3] Biogen Inc, Cambridge, MA 02142 USA

[4] Chemveda Life Sci Inc, San Diego, CA 92121 USA

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 11期

关键词：

DERIVATIVES; PROTEIN; ACCESS;

D O I：

10.1021/acs.orglett.4c00474

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple protocol is outlined herein for rapid access to enantiopure unnatural amino acids (UAAs) from trivial glutamate and aspartate precursors. The method relies on Ag/Ni-electrocatalytic decarboxylative coupling and can be rapidly conducted in parallel (24 reactions at a time) to ascertain coupling viability followed by scale-up for the generation of useful quantities of UAAs for exploratory studies.

引用

收藏

页码：2276 / 2281

页数：6

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