Hypoxia signaling and metastatic progression

被引：10

作者：

Schito, Luana ^{[1
,2
]}

Rey-Keim, Sergio ^{[1
,2
]}

机构：

[1] Univ Coll Dublin, UCD Sch Med, Dublin D04 C7X2 4, Ireland

[2] Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Belfield D04 C7X2, Dublin, Ireland

来源：

SEMINARS IN CANCER BIOLOGY | 2023年 / 97卷

关键词：

Cancer; Hypoxia; HIFs; UPR; Migration; Metastasis; Invasion; UNFOLDED PROTEIN RESPONSE; INDUCIBLE FACTOR-I; TRANSCRIPTION FACTOR SNAIL; TO-MESENCHYMAL TRANSITION; CADHERIN GENE-EXPRESSION; CARCINOMA CELL INVASION; BREAST-TUMOR CELLS; CANCER-CELLS; NICHE FORMATION; STROMA RATIO;

D O I：

10.1016/j.semcancer.2023.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Disruption of oxygen homeostasis, resulting from an imbalance between O2 supply and demand during malignant proliferation, leads to the development of hypoxic tumor microenvironments that promote the acquisition of aggressive cancer cell phenotypes linked to metastasis and patient mortality. In this review, the mechanistic links between tumor hypoxia and metastatic progression are presented. Current status and perspectives of targeting hypoxia signaling pathways as a strategy to halt cancer cell metastatic activities are emphasized.

引用

页码：42 / 49

页数：8

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