Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project

被引：1

作者：

Song, Minkyo ^{[1
]}

Jayasekara, Harindra ^{[2
,3
,4
]}

Pelucchi, Claudio ^{[5
]}

Rabkin, Charles S. ^{[1
]}

Johnson, Kenneth C. ^{[6
]}

Hu, Jinfu ^{[7
]}

Palli, Domenico ^{[8
]}

Ferraroni, Monica ^{[5
]}

Liao, Linda M. ^{[1
]}

Bonzi, Rossella ^{[5
]}

Zaridze, David ^{[9
]}

Maximovitch, Dmitry ^{[9
]}

Aragones, Nuria ^{[10
,11
]}

Martin, Vicente ^{[10
,12
]}

Castano-Vinyals, Gemma ^{[10
,13
,14
,15
]}

Guevara, Marcela ^{[10
,16
,17
]}

Tsugane, Shoichiro ^{[18
,19
]}

Hamada, Gerson Shigueaki ^{[20
]}

Hidaka, Akihisa ^{[18
]}

Negri, Eva ^{[21
]}

Ward, Mary H. ^{[1
]}

Sinha, Rashmi ^{[1
]}

Lagiou, Areti ^{[22
]}

Lagiou, Pagona ^{[23
,24
]}

Boffetta, Paolo ^{[21
,25
]}

Curado, Maria Paula ^{[26
]}

Lunet, Nuno ^{[27
,28
,29
]}

Vioque, Jesus ^{[10
,30
]}

Zhang, Zuo-Feng ^{[31
,32
]}

La Vecchia, Carlo ^{[5
]}

Camargo, M. Constanza ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA

[2] Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia

[3] Monash Univ, Fac Med Nursing & Hlth Sci, Sch Publ Hlth & Prevent Med, Clayton, Vic, Australia

[4] Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

[5] Univ Milan, Dept Clin Sci & Community Hlth, Branch Med Stat Biometry & Epidemiol GA Maccacaro, Milan, Italy

[6] Univ Ottawa, Sch Epidemiol & Publ Hlth, Dept Med, Ottawa, ON, Canada

[7] Harbin Med Univ, Harbin, Peoples R China

[8] ISPRO, Inst Canc Res, Canc Risk Factors & Life Style Epidemiol Unit, Prevent & Clin Network, Florence, Italy

[9] NN Blokhin Natl Med Res Ctr Oncol, Dept Clin Epidemiol, Moscow, Russia

[10] Consortium Biomed Res Epidemiol & Publ Hlth CIBERE, Madrid, Spain

[11] Dept Hlth Madrid, Publ Hlth Div, Canc Registrat & Surveillance Unit, Madrid, Spain

[12] Univ Leon, Inst Biomed IBIOMED, Leon, Spain

[13] Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain

[14] Hosp Mar, Med Res Inst, IMIM, Barcelona, Spain

[15] Univ Pompeu Fabra UPF, Barcelona, Spain

[16] Inst Salud Publ & Laboral Navarra, Pamplona 31003, Spain

[17] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain

[18] Natl Canc Ctr, Epidemiol & Prevent Grp, Ctr Publ Hlth Sci, Tokyo, Japan

[19] Natl Inst Biomed Innovat Hlth & Nutr, Natl Inst Hlth & Nutr, Tokyo, Japan

[20] Nikkei Dis Prevent Ctr, Sao Paulo, Brazil

[21] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy

[22] Univ West Attica, Sch Publ Hlth, Dept Publ & Community Hlth, Athens, Greece

[23] Natl & Kapodistrian Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece

[24] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[25] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY USA

[26] AC Camargo Canc Ctr, Ctr Int Pesquisa, Sao Paulo, Brazil

[27] Univ Porto, EPIUnit, Inst Saude Publ, Porto, Portugal

[28] Lab Invest Integrat & Translac Saude Populac ITR, Porto, Portugal

[29] Univ Porto, Dept Ciencias Saude Publ & Forenses & Educ Med, Fac Med, Porto, Portugal

[30] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain

[31] UCLA, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA USA

[32] Jonsson Comprehens Canc Ctr, Los Angeles, CA USA

来源：

CANCER CAUSES & CONTROL | 2024年 / 35卷 / 04期

关键词：

Estrogens; MHT; Premenopause; Postmenopause; JAPANESE BRAZILIANS; ALCOHOL-CONSUMPTION; FAMILY-HISTORY; SEX-HORMONES; ADENOCARCINOMA; SERUM; DEHYDROEPIANDROSTERONE; METAANALYSIS; SMOKING; SULFATE;

D O I：

10.1007/s10552-023-01829-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium.Methods A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer were estimated by pooling study-specific ORs using random-effects meta-analysis.Results A duration of fertility of >= 40 years (vs. < 20), was associated with a 25% lower risk of gastric cancer (OR = 0.75; 95% CI: 0.58-0.96). Compared with never use, ever, 5-9 years and >= 10 years use of MHT in postmenopausal women, showed ORs of 0.73 (95% CI: 0.58-0.92), 0.53 (95% CI: 0.34-0.84) and 0.71 (95% CI: 0.50-1.00), respectively. The associations were generally similar for anatomical and histologic subtypes.Conclusion Our results support the hypothesis that reproductive factors and MHT use may lower the risk of gastric cancer in women, regardless of anatomical or histologic subtypes. Given the variation in hormones over the lifespan, studies should address their effects in premenopausal and postmenopausal women. Furthermore, mechanistic studies may inform potential biological processes.

引用

页码：727 / 737

页数：11

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