BRCA1/BRCA2-Associated Pancreatic Cancer: Case Series

被引：0
作者：
Polyakova, Vera [1 ]
Bodunova, Natalia [1 ]
Khatkov, Igor [1 ]
Feoktistova, Polina [1 ]
Kolyago, Elena [1 ]
Agami, Paul [1 ]
Baychorov, Magomet [1 ]
Yanova, Tatiana [1 ]
机构：
[1] Moscow Clin Sci Ctr, Moscow, Russia
来源：
BIONANOSCIENCE | 2024年 / 14卷 / 01期
关键词：
BRCA1/BRCA2; mutation; Pancreatic cancer; Treatment; BRCA MUTATIONS;
D O I：
10.1007/s12668-023-01219-6
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The presence of a mutation in the BRCA1/2 genes makes it possible to use platinum drugs and PARP inhibitors in patients with pancreatic cancer. Conducting molecular genetic testing allows you to assess the risk of developing malignant neoplasms in a patient and his relatives. We present a series of clinical cases of patients with pancreatic cancer associated with BRCA 1/2. Conducting molecular genetic testing allows you to assess the risk of developing malignant neoplasms in a patient and his relatives. A burdened family history is an indication for molecular genetic diagnosis to identify a pathogenic variant and the possibility of prescribing observation to detect a malignant neoplasm at an early stage.
引用
收藏
页码：337 / 345
页数：9
相关论文
共 11 条
  • [1] Frequency and Significance of Abnormal Pancreatic Imaging in Patients with BRCA1 and BRCA2 Genetic Mutations
    Chahla, Elie
    Cheesman, Antonio
    Mahon, Suzanne M.
    Garrett, Robert W.
    Bradenham, Ben P., Jr.
    Schwartz, Theresa L.
    Omran, Louay
    Taylor, Jason R.
    Alkaade, Samer
    [J]. SCIENTIFICA, 2016, 2016
  • [2] Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021
    Daly, Mary B.
    Pal, Tuya
    Berry, Michael P.
    Buys, Saundra S.
    Dickson, Patricia
    Domchek, Susan M.
    Elkhanany, Ahmed
    Friedman, Susan
    Goggins, Michael
    Hutton, Mollie L.
    Karlan, Beth Y.
    Khan, Seema
    Klein, Catherine
    Kohlmann, Wendy
    Kurian, Allison W.
    Laronga, Christine
    Litton, Jennifer K.
    Mak, Julie S.
    Menendez, Carolyn S.
    Merajver, Sofia D.
    Norquist, Barbara S.
    Offit, Kenneth
    Pederson, Holly J.
    Reiser, Gwen
    Senter-Jamieson, Leigha
    Shannon, Kristen Mahoney
    Shatsky, Rebecca
    Visvanathan, Kala
    Weitzel, Jeffrey N.
    Wick, Myra J.
    Wisinski, Kari B.
    Yurgelun, Matthew B.
    Darlow, Susan D.
    Dwyer, Mary A.
    [J]. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2021, 19 (01): : 77 - 102
  • [3] Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer
    Golan, Talia
    Hammel, Pascal
    Reni, Michele
    Van Cutsem, Eric
    Macarulla, Teresa
    Hall, Michael J.
    Park, Joon-Oh
    Hochhauser, Daniel
    Arnold, Dirk
    Oh, Do-Youn
    Reinacher-Schick, Anke
    Tortora, Giampaolo
    Alguel, Hana
    O'Reilly, Eileen M.
    McGuinness, David
    Cui, Karen Y.
    Schlienger, Katia
    Locker, Gershon Y.
    Kindler, Hedy L.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (04) : 317 - 327
  • [4] Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer
    Golan, Talia
    Sella, Tal
    O'Reilly, Eileen M.
    Katz, Matthew H. G.
    Epelbaum, Ron
    Kelsen, David P.
    Borgida, Ayelet
    Maynard, Hannah
    Kindler, Hedy
    Friedmen, Eitan
    Javle, Milind
    Gallinger, Steven
    [J]. BRITISH JOURNAL OF CANCER, 2017, 116 (06) : 697 - 702
  • [5] Effects of lipid based Multiple Micronutrients Supplement on the birth outcome of underweight pre-eclamptic women: A randomized clinical trial
    Mohammad, Nabila Sher
    Nazli, Rubina
    Zafar, Hafsa
    Fatima, Sadia
    [J]. PAKISTAN JOURNAL OF MEDICAL SCIENCES, 2022, 38 (01) : 219 - 226
  • [6] Genetic epidemiology of BRCA mutations - family history detects less than 50% of the mutation carriers
    Moller, Pal
    Hagen, Anne Irene
    Apold, Jaran
    Maehle, Louise
    Clark, Neal
    Fiane, Bent
    Lovslett, Kjell
    Hovig, Eivind
    Vabo, Anita
    [J]. EUROPEAN JOURNAL OF CANCER, 2007, 43 (11) : 1713 - 1717
  • [7] Response and Survival Associated With First-line FOLFIRINOX vs Gemcitabine and nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma
    Perri, Giampaolo
    Prakash, Laura
    Qiao, Wei
    Varadhachary, Gauri R.
    Wolff, Robert
    Fogelman, David
    Overman, Michael
    Pant, Shubham
    Javle, Milind
    Koay, Eugene J.
    Herman, Joseph
    Kim, Michael
    Ikoma, Naruhiko
    Tzeng, Ching-Wei
    Lee, Jeffrey E.
    Katz, Matthew H. G.
    [J]. JAMA SURGERY, 2020, 155 (09) : 832 - 839
  • [8] BRCA mutated pancreatic cancer: A change is coming
    Rosen, Michael N.
    Goodwin, Rachel A.
    Vickers, Michael M.
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2021, 27 (17) : 1943 - 1958
  • [9] Cancer Statistics, 2017
    Siegel, Rebecca L.
    Miller, Kimberly D.
    Jemal, Ahmedin
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2017, 67 (01) : 7 - 30
  • [10] Pancreatic Cancer with Mutation in BRCA1/2, MLH1, and APC Genes: Phenotype Correlation and Detection of a Novel Germline BRCA2 Mutation
    Vietri, Maria Teresa
    D'Elia, Giovanna
    Caliendo, Gemma
    Albanese, Luisa
    Signoriello, Giuseppe
    Napoli, Claudio
    Molinari, Anna Maria
    [J]. GENES, 2022, 13 (02)
12