Circular RNAs: characteristics, functions, mechanisms, and potential applications in thyroid cancer

被引：3

作者：

Wu, Mengmeng ^{[1
]}

Yuan, Haibin ^{[2
]}

Zou, Weiwei ^{[1
]}

Xu, Shujian ^{[1
]}

Liu, Song ^{[1
]}

Gao, Qiang ^{[1
]}

Guo, Qingqun ^{[1
]}

Han, Yong ^{[1
]}

An, Xingguo ^{[1
]}

机构：

[1] Binzhou Med Univ Hosp, Dept Thyroid Surg, Binzhou 256603, Shandong, Peoples R China

[2] Binzhou Med Univ Hosp, Dept Hlth Management, Binzhou 256603, Shandong, Peoples R China

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2024年 / 26卷 / 04期

关键词：

circRNAs; Thyroid cancer; Diagnosis; Prognosis; Molecular mechanism; Pathways; SIGNALING PATHWAY; COMPREHENSIVE DATABASE; EXPRESSION PROFILES; CARCINOMA; PROMOTES; CIRCRNA; PROLIFERATION; PROGRESSION; METASTASIS; IDENTIFICATION;

D O I：

10.1007/s12094-023-03324-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thyroid cancer (TC) is one of the most common endocrine malignancies, and its incidence has increased globally. Despite extensive research, the underlying molecular mechanisms of TC remain partially understood, warranting continued exploration of molecular markers for diagnostic and prognostic applications. Circular RNAs (circRNAs) have recently garnered significant attention owing to their distinct roles in cancers. This review article introduced the classification and biological functions of circRNAs and summarized their potential as diagnostic and prognostic markers in TC. Further, the interplay of circRNAs with PI3K/Akt/mTOR, Wnt/beta-catenin, MAPK/ERK, Notch, JAK/STAT, and AMPK pathways is elaborated upon. The article culminates with an examination of circRNA's role in drug resistance of TC and highlights the challenges in circRNA research in TC.

引用

页码：808 / 824

页数：17

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