A biosensor based on Fe3O4@ MXene-Au nanocomposites with high peroxidase-like activity for colorimetric and smartphone-based detection of glucose

被引:20
作者
Fei, Jianwen [1 ]
Yang, Wei [1 ]
Dai, Yin [1 ]
Xu, Wei [1 ]
Fan, Huizhu [1 ]
Zheng, Yani [1 ]
Zhang, Jun [1 ]
Zhu, Wanying [1 ]
Hong, Junli [1 ]
Zhou, Xuemin [1 ]
机构
[1] Nanjing Med Univ, Sch Pharm, Nanjing 211166, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
Peroxidase-like activity; Nanozyme; Glucose biosensor; Agarose hydrogel; Smartphone-based platform; Colorimetry;
D O I
10.1007/s00604-023-05900-1
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A novel magnetic nanozyme Fe3O4@ MXene-Au nanocomposite, which possessed higher peroxidase-like activity than that of Fe3O4 nanoparticles and Fe3O4@ MXene nanocomposites, was developed. The outstanding magnetic properties of the nanozyme endowed it with the ability of simple and rapid separation, achieving great recyclability. Based on Fe3O4@ MXene-Au nanocomposites and glucose oxidase (Glu Ox), a highly selective colorimetric biosensor for glucose detection was developed. Fe3O4@ MXene-Au nanocomposites can catalyze H2O2 produced from glucose catalyzed by glucose oxidase to center dot OH and oxidize colorless 3,3',5,5'-tetramethylbenzidine (TMB) to blue oxidized TMB (oxTMB) with a significant absorbance at 652 nm. The linear range of glucose was 0-1.4 mM under optimal conditions, with a limit of detection (LOD) of 0.11 mM. Glucose in human whole blood was successfully detected with satisfactory recoveries. Furthermore, a facile agarose hydrogel detection platform was designed. With smartphone software, glucose detection can be realized by the agarose hydrogel platform, demonstrating the potential in on-site and visual detection of glucose.
引用
收藏
页数:11
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