Herbal medicine and its impact on the gut microbiota in colorectal cancer

被引:11
作者
Bu, Fan [1 ]
Tu, Yifeng [2 ]
Wan, Ziang [1 ]
Tu, Shiliang [1 ]
机构
[1] Hangzhou Med Coll, Affiliated Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Colorectal Surg, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Chinese Med Univ, Affiliated Coll 2, Hangzhou, Zhejiang, Peoples R China
关键词
microbial metabolism; gut microbiota; herbal medicine; colorectal cancer; bile acids; CHAIN FATTY-ACIDS; FUSOBACTERIUM-NUCLEATUM; COLON CARCINOGENESIS; BILE-ACIDS; GERM-FREE; INHIBITION; CELLS; BIFIDOBACTERIUM; PROLIFERATION; TUMORIGENESIS;
D O I
10.3389/fcimb.2023.1096008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It is well-established that there are trillions of gut microbiota (GM) in the human gut. GM and its metabolites can reportedly cause cancer by causing abnormal immune responses. With the development of sequencing technology and the application of germ-free models in recent years, significant inroads have been achieved in research on GM and microbiota-related metabolites. Accordingly, the role and mechanism of GM in colorectal cancer (CRC) development have been gradually revealed. Traditional Chinese medicine (TCM) represents an important source of natural medicines and herbal products, with huge potential as anti-CRC agents. The potential application of TCM to target gut microbes for the treatment of colorectal cancer represents an exciting area of investigation.
引用
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页数:12
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